Haemodynamic and catecholamine response to simulated ventricular tachycardia in man: effect of baseline left ventricular function

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dc.contributor.authorKolettis, T. M.en
dc.contributor.authorPsarros, E.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorSideris, D. A.en
dc.date.accessioned2015-11-24T19:14:27Z
dc.date.available2015-11-24T19:14:27Z
dc.identifier.issn1468-201X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21313
dc.rightsDefault Licence-
dc.subjectBlood Pressure/*physiologyen
dc.subjectCardiac Pacing, Artificialen
dc.subjectCatecholamines/*blooden
dc.subjectCohort Studiesen
dc.subjectEpinephrine/blooden
dc.subjectFemaleen
dc.subjectHemodynamicsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNorepinephrine/blooden
dc.subjectStroke Volume/*physiologyen
dc.subjectTachycardia, Ventricular/blood/*physiopathologyen
dc.subjectVentricular Dysfunction, Left/*physiopathologyen
dc.subjectVentricular Function, Left/*physiologyen
dc.titleHaemodynamic and catecholamine response to simulated ventricular tachycardia in man: effect of baseline left ventricular functionen
heal.abstractOBJECTIVE: To examine the effects of baseline left ventricular function on the haemodynamic and catecholamine responses to ventricular tachycardia. DESIGN: Experimental cohort study. SETTING: Cardiac catheterisation laboratory in tertiary referral centre. SUBJECTS: 24 patients (19 male, 5 female; mean (SD) age, 59 (10) years) without coronary artery disease, divided into two groups with normal or impaired left ventricular function: group A, ejection fraction > 65% (n = 10); group B, ejection fraction < 45% (n = 14). Other medical and demographic factors were similar in the two groups. INTERVENTIONS: Ventricular tachycardia was simulated with rapid pacing at 150 beats/min for 10 minutes. MAIN OUTCOME MEASURES: Arterial blood pressure; venous plasma catecholamine concentrations. RESULTS: During rapid pacing, blood pressure was lower in group B (with impaired left ventricular function) than in group A: systolic blood pressure, 102 (11) v 115 (9) mm Hg (p = 0.005); mean blood pressure, 79 (6) v 85 (6) mm Hg (p = 0.02). The ejection fraction correlated with the lowest systolic blood pressure (r = 0.64, p = 0.0006). Although the rise in adrenaline was comparable between the two groups, the rise in noradrenaline was more pronounced (p < 0.05) in patients in group B. CONCLUSION: At low rates and in selected patients, the underlying state of left ventricular function affects haemodynamic tolerance of ventricular tachycardia. Patients with impaired left ventricular function have a lower blood pressure during ventricular tachycardia, despite an exaggerated noradrenaline release.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12591837-
heal.journalNameHearten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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