Effects of hypercholesterolaemia on Leydig and Sertoli cell secretory function and the overall sperm fertilizing capacity in the rabbit

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dc.contributor.authorYamamoto, Y.en
dc.contributor.authorShimamoto, K.en
dc.contributor.authorSofikitis, N.en
dc.contributor.authorMiyagawa, I.en
dc.date.accessioned2015-11-24T19:21:10Z
dc.date.available2015-11-24T19:21:10Z
dc.identifier.issn0268-1161-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22086
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectBody Temperatureen
dc.subjectCholesterol/analysisen
dc.subjectCholesterol, Dietary/administration & dosageen
dc.subjectChorionic Gonadotropin/pharmacologyen
dc.subjectEpididymis/pathologyen
dc.subject*Fertilization in Vitroen
dc.subjectHumansen
dc.subjectHypercholesterolemia/etiology/*physiopathologyen
dc.subjectLeydig Cells/*physiologyen
dc.subjectMaleen
dc.subjectOrgan Sizeen
dc.subjectRabbitsen
dc.subjectSemen/chemistryen
dc.subjectSertoli Cells/*physiologyen
dc.subjectSperm Counten
dc.subjectSperm Motilityen
dc.subjectSpermatogenesisen
dc.subjectSpermatozoa/*physiologyen
dc.subjectTestis/chemistry/pathology/*physiopathologyen
dc.subjectTestosterone/blooden
dc.titleEffects of hypercholesterolaemia on Leydig and Sertoli cell secretory function and the overall sperm fertilizing capacity in the rabbiten
heal.abstractThe effects of hypercholesterolaemia on testicular endocrine and exocrine function were evaluated. The influence of hypercholesterolaemia on sperm quality, quantity, and fertilizing potential was also determined. Ten mature rabbits (group A) were fed chow containing 3% cholesterol for 12 weeks. Ten control rabbits (group B) were fed normal chow for the same period. At the end of the experimental period testosterone profiles and sperm parameters were evaluated and the sperm reproductive potential was assessed by in vitro fertilization (IVF) techniques. Peripheral serum testosterone responses to testicular stimulation with human chorionic gonadotrophin, androgen-binding protein activity in testicular cytosols, sperm concentration, sperm motility, length of sperm midpiece, and IVF outcome were all significantly lower in group A than in group B. In contrast, serum cholesterol concentrations were significantly higher in group A. There were no significant differences in either testicular versus intra-abdominal temperature differences or cholesterol concentrations in seminal plasma or testicular tissue between groups A and B. The results suggest that hypercholesterolaemia has a detrimental effect on Leydig and Sertoli cell secretory function, spermatogenesis, epididymal sperm maturation process, and the overall sperm fertilizing capacity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10357968-
heal.identifier.secondaryhttp://humrep.oxfordjournals.org/content/14/6/1516.full.pdf-
heal.journalNameHum Reproden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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