Effects of sulfhydryl compounds on cancer cell lines: I: N-(2-mercaptopropionyl)-glycine exerts antiproliferating effects and antagonizes the stimulating effect of prolactin on MCF-7 human breast cancer cells
| dc.contributor.author | Malamas, F. M. | en |
| dc.contributor.author | Thomas, C. G. | en |
| dc.contributor.author | Stefos, T. | en |
| dc.contributor.author | Evangelou, A. | en |
| dc.date.accessioned | 2015-11-24T19:20:32Z | |
| dc.date.available | 2015-11-24T19:20:32Z | |
| dc.identifier.issn | 0258-851X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22047 | |
| dc.rights | Default Licence | - |
| dc.subject | Breast Neoplasms | en |
| dc.subject | Cell Division/*drug effects | en |
| dc.subject | Cell Line, Tumor | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Prolactin/*pharmacology | en |
| dc.subject | Sulfhydryl Compounds/*pharmacology | en |
| dc.subject | Tiopronin/*pharmacology | en |
| dc.title | Effects of sulfhydryl compounds on cancer cell lines: I: N-(2-mercaptopropionyl)-glycine exerts antiproliferating effects and antagonizes the stimulating effect of prolactin on MCF-7 human breast cancer cells | en |
| heal.abstract | The effects of prolactin (PRL) and N-(2-mercaptopropionyl)-glycine (MPG) on the growth of MCF-7 human breast cancer cells, and the influence of MPG on PRL-induced MCF- 7 cell proliferation, when added simultaneously to the culture medium, were examined. Prolactin at concentrations of 200 ng/ml - 350 ng/ml enhanced the growth of MCF-7 cells, while at lower and higher concentrations its action was diminished. MPG alone at concentrations above 2 mM caused a decrease in cell proliferation. When PRL and MPG were added simultaneously to the culture medium, an inhibitory effect on PRL-induced MCF-7 cell proliferation was observed, at concentrations of MPG lower than 2 mM. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/17436584 | - |
| heal.journalName | In Vivo | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2007 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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