Leptin and adiponectin levels in patients with ankylosing spondylitis. The effect of infliximab treatment
Φόρτωση...
Ημερομηνία
Συγγραφείς
Derdemezis, C. S.
Filippatos, T. D.
Voulgari, P. V.
Tselepis, A. D.
Drosos, A. A.
Kiortsis, D. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Exp Rheumatol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background. Adipose tissue-derived leptin and adiponectin control hunger, energy expenditure, insulin sensitivity, endothelial function, reproduction and immunity and are thought to play a role in autoimmune diseases. However, their role in ankylosing spondylitis (AS) is not clearly defined. Tumour necrosis factor TNF-alpha is a potential modulator of adipocytokines. The effect of long-term anti-TNF-alpha treatment on plasma levels of leptin and adiponectin has not been assessed so far. Objectives. To assess the effect of a 6-month anti-TNF-alpha treatment on serum leptin and adiponectin levels in AS patients. Methods. Thirty men with AS were included in the study. Thirty age- and weight-matched men served as controls. Clinical and biochemical parameters were assessed and serum levels of leptin and adiponectin were measured with enzyme immunoassay methods prior to and after the 6-month treatment with infliximab. Results. Mean age and disease duration of AS patients were 40.6+/-13.7 and 13.4+/-8.4 years, respectively. At baseline, AS patients exhibited significantly higher adiponectin (15.4+/-8.3 vs. 8.6+/-4.2 p<0.05), but no difference in leptin levels (7.2+/-2.9 vs. 8.9+/-6.4 ng/ml, p=NS). Adipocytokines did not correlate with any disease parameter. Body weight of the patients did not change significantly over the 6-month period. Serum levels of leptin and adiponectin did not change significantly otter the 6-month treatment. Conclusion. Adiponectin levels were significantly higher in AS patients compared with controls. Infliximab treatment did not change serum levels of leptin and adiponectin suggesting that the anti-TNF-alpha treatment may not modulate significantly their levels.
Περιγραφή
Λέξεις-κλειδιά
ankylosing spondylitis, infliximab, tnf, leptin, adiponectin, rheumatoid-arthritis, adipose-tissue, disease-activity, plasma-levels, inflammation, adipokines, therapy, index, mediators, insulin
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000286918800012
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας