Loss of Dopamine D2 Receptors Induces Atrophy in the Temporal and Parietal Cortices and the Caudal Thalamus of Ethanol-Consuming Mice
Φόρτωση...
Ημερομηνία
Συγγραφείς
Delis, F.
Benveniste, H.
Xenos, M.
Grandy, D.
Wang, G. J.
Volkow, N. D.
Thanos, P. K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Wiley-Blackwell
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Alcoholism-Clinical and Experimental Research
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background: The need of an animal model of alcoholism becomes apparent when we consider the genetic diversity of the human populations, an example being dopamine D2 receptor (DRD2) expression levels. Research suggests that low DRD2 availability is associated with alcohol abuse, while higher DRD2 levels may be protective against alcoholism. This study aims to establish whether (i) the ethanol-consuming mouse is a suitable model of alcohol-induced brain atrophy and (ii) DRD2 protect the brain against alcohol toxicity. Methods: Adult Drd2+/+ and Drd2-/- mice drank either water or 20% ethanol solution for 6 months. At the end of the treatment period, the mice underwent magnetic resonance (MR) imaging under anesthesia. MR images were registered to a common space, and regions of interest were manually segmented. Results: We found that chronic ethanol intake induced a decrease in the volume of the temporal and parietal cortices as well as the caudal thalamus in Drd2-/- mice. Conclusions: The result suggests that (i) normal DRD2 expression has a protective role against alcohol-induced brain atrophy and (ii) in the absence of Drd2 expression, prolonged ethanol intake reproduces a distinct feature of human brain pathology in alcoholism, the atrophy of the temporal and parietal cortices.
Περιγραφή
Λέξεις-κλειδιά
d2 receptors, ethanol, brain, mri, mouse, prenatal alcohol exposure, matter volume loss, gray-matter, hippocampal volume, agonists protect, heavy drinking, deficient mice, brain volumes, dependence, individuals
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000303388500009
http://onlinelibrary.wiley.com/store/10.1111/j.1530-0277.2011.01667.x/asset/j.1530-0277.2011.01667.x.pdf?v=1&t=h3b5rf3s&s=d6b39523539af260feeb66fb9617967b15b7b517
http://onlinelibrary.wiley.com/store/10.1111/j.1530-0277.2011.01667.x/asset/j.1530-0277.2011.01667.x.pdf?v=1&t=h3b5rf3s&s=d6b39523539af260feeb66fb9617967b15b7b517
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικών