Volume and flow dependence of respiratory mechanics in mechanically ventilated COPD patients

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dc.contributor.authorVassiliou, M. P.en
dc.contributor.authorAmygdalou, A.en
dc.contributor.authorPsarakis, C. J.en
dc.contributor.authorDalavanga, Y.en
dc.contributor.authorVassiliou, P. M.en
dc.contributor.authorMandragos, K. E.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorBehrakis, P. K.en
dc.date.accessioned2015-11-24T19:37:35Z
dc.date.available2015-11-24T19:37:35Z
dc.identifier.issn1569-9048-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24053
dc.rightsDefault Licence-
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Models, Biologicalen
dc.subjectPositive-Pressure Respiration/methodsen
dc.subjectPulmonary Disease, Chronic Obstructive/*physiopathology/therapyen
dc.subjectPulmonary Ventilation/*physiologyen
dc.subject*Respiration, Artificialen
dc.titleVolume and flow dependence of respiratory mechanics in mechanically ventilated COPD patientsen
heal.abstractVolume and flow dependencies of respiratory mechanics are examined in 10 COPD patients under mechanical ventilation (MV) at 3 levels of externally applied PEEP (PEEPe). Airways pressure (Paw), flow (V') and volume (V) data are analyzed according to (1) the linear and (2) a non-linear model, accounting for volume dependence of elastance and for flow and volume dependence of resistance. The models' fitness to data is assessed by the regression errors. Non-linear modelling fits significantly better to data, while the difference of fitness decreases with PEEPe. Linear mechanics are not significantly different between the 3 levels of PEEPe. A positive volume dependence of elastance observed at 0, decreases at 5 and increases again at 10 hPa of PEEPe. A seriously negative volume dependence of resistance at 0 turned to positive with PEEPe. These dependencies of respiratory mechanics during COPD under MV, show that the present non-linear respiratory mechanical monitoring may help for better and less risky adjustment of PEEPe.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12706068-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1569904803000648/1-s2.0-S1569904803000648-main.pdf?_tid=31f4a7dda044a24a4135c0a857733052&acdnat=1333606025_389f222cf7910090640eaf33ef3bbd6f-
heal.journalNameRespir Physiol Neurobiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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