Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin
| dc.contributor.author | Batistatou, A. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Nakanishi, Y. | en |
| dc.contributor.author | Vagianos, C. | en |
| dc.contributor.author | Hirohashi, S. | en |
| dc.contributor.author | Agnantis, N. J. | en |
| dc.contributor.author | Scopa, C. D. | en |
| dc.date.accessioned | 2015-11-24T19:24:28Z | |
| dc.date.available | 2015-11-24T19:24:28Z | |
| dc.identifier.issn | 1046-3976 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22483 | |
| dc.rights | Default Licence | - |
| dc.subject | Cadherins/*metabolism | en |
| dc.subject | Carcinoma, Papillary, Follicular/*metabolism/*pathology | en |
| dc.subject | Gene Expression | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Membrane Glycoproteins/*biosynthesis | en |
| dc.subject | Neoplasm Proteins/*biosynthesis | en |
| dc.subject | Thyroid Neoplasms/*metabolism/*pathology | en |
| dc.title | Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin | en |
| heal.abstract | Dysadherin is a novel glycoprotein, with an anti-cell-cell adhesion function. The aim of the present study was to examine the expression of dysadherin in thyroid papillary microcarcinoma (PMC), to associate it with the expression of E-cadherin and to investigate whether there are differences with papillary carcinoma (PC). A statistically significant difference in dysadherin and E-cadherin expression between PC and PMC and a negative correlation between E-cadherin and dysadherin expression regardless of tumor size were noted. Based on these findings it is hypothesized that retained cell-cell adhesion, through maintenance of the E-cadherin adhesion system, in PMC prevents neoplastic cells from dissociating easily from each other and metastasizing. Increased dysadherin expression is possibly one of the post-transcriptional mechanisms responsible for E-cadherin downregulation in thyroid papillary neoplasia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s12022-008-9035-1 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18677652 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/jq321tjmn8j17w53/fulltext.pdf | - |
| heal.journalName | Endocr Pathol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2008 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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