Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorAbrams, E. J.en
dc.contributor.authorAmmann, A.en
dc.contributor.authorBulterys, M.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorGray, L.en
dc.contributor.authorKorber, B. T.en
dc.contributor.authorMayaux, M. J.en
dc.contributor.authorMofenson, L. M.en
dc.contributor.authorNewell, M. L.en
dc.contributor.authorShapiro, D. E.en
dc.contributor.authorTeglas, J. P.en
dc.contributor.authorWilfert, C. M.en
dc.date.accessioned2015-11-24T18:59:36Z
dc.date.available2015-11-24T18:59:36Z
dc.identifier.issn0022-1899-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19385
dc.rightsDefault Licence-
dc.subjectAnti-HIV Agents/therapeutic useen
dc.subjectClinical Trials as Topicen
dc.subjectEuropeen
dc.subjectFemaleen
dc.subjectGestational Ageen
dc.subjectHIV Infections/drug therapy/*transmission/virologyen
dc.subjectHIV-1/*physiologyen
dc.subjectHumansen
dc.subjectInfant, Newbornen
dc.subject*Infectious Disease Transmission, Verticalen
dc.subjectInternational Cooperationen
dc.subjectPregnancyen
dc.subjectPregnancy Complications, Infectious/drug therapy/*virologyen
dc.subjectProspective Studiesen
dc.subjectRNA, Viral/*blooden
dc.subjectRegistriesen
dc.subjectRisk Factorsen
dc.subjectUnited Statesen
dc.subject*Viral Loaden
dc.subjectViremiaen
dc.titlePerinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/mlen
heal.abstractIn a collaboration of 7 European and United States prospective studies, 44 cases of vertical human immunodeficiency virus type 1 (HIV-1) transmission were identified among 1202 women with RNA virus loads <1000 copies/mL at delivery or at the measurement closest to delivery. For mothers receiving antiretroviral treatment during pregnancy or at the time of delivery (or both), there was a 1.0% transmission rate (8 of 834; 95% confidence interval [CI], 0.4%-1.9%), compared with 9.8% (36 of 368; 95% CI, 7.0%-13.4%) for untreated mothers (risk ratio, 0.10; 95% CI, 0.05-0.21). In multivariate analysis adjusting for study, transmission was lower with antiretroviral treatment (odds ratio [OR], 0.10; P<.001), cesarean section (OR, 0.30; P=.022), greater birth weight (P=.003), and higher CD4 cell count (P=.039). In 12 of 44 cases, multiple RNA measurements were obtained during pregnancy or at the time of delivery or within 4 months after giving birth; in 10 of the 12 cases, the geometric mean virus load was >500 copies/mL. Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1086/318530-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11170978-
heal.identifier.secondaryhttp://jid.oxfordjournals.org/content/183/4/539.full.pdf-
heal.journalNameJ Infect Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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