Soluble interleukin-2 receptors in patients with advanced colorectal carcinoma
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Date
Authors
Pavlidis, N.
Nicolaides, C.
Bairaktari, E.
KalefEzra, J.
Athanassiadis, A.
Seferiadis, C.
Fountzilas, G.
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peer-reviewed
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International Journal of Biological Markers
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Description
The levels of soluble interleukin-2 receptors (slL-2R) were measured in the serum of 52 patients with advanced colorectal carcinoma and compared to CEA and CA 19-9 levels. Twenty-five normal, age and sex-matched individuals sewed as controls. Seventy-five per cent of the patients had increased mean serum levels of slL-2R (1539 +/- 155 U/ml), while normal controls had mean levels of 555 +/- 31 U/ml (p < 0.001). The relationship with hepatic or lymph nodal metastases showed no statistically significant difference (p=0.34 and p=0.47, respectively). Serum slL-2R levels showed a Linear correlation with CEA (p < 0.05). Patients with lower pretreatment slL-2R levels (less than 1.200 U/ml) had a longer survival than patients with higher initial levels (more than 1.200 U/ml) (p=0.0049). In conclusion, the present work shows that the serum levels of slL-2R: a) are elevated in patients with advanced colorectal cancer, b) have no relationship with the type of metastases, c) correlate with serum CEA and d) have a prognostic value for survival.
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Keywords
soluble interleukin-2 receptors, cea, ca 19-9, colorectal cancer, tumor markers, disease-activity, serum levels, cancer, leukemia, antigen, cells
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<Go to ISI>://A1996UR30600002
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής