Severe muscle weakness due to hypokalemia as a manifestation of small-cell carcinoma
| dc.contributor.author | Konstantinidis, A. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Panteli, K. | en |
| dc.contributor.author | Constantopoulos, S. | en |
| dc.date.accessioned | 2015-11-24T18:51:52Z | |
| dc.date.available | 2015-11-24T18:51:52Z | |
| dc.identifier.issn | 0025-7931 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18320 | |
| dc.rights | Default Licence | - |
| dc.subject | ACTH Syndrome, Ectopic/etiology | en |
| dc.subject | Antineoplastic Agents/therapeutic use | en |
| dc.subject | Carboplatin/therapeutic use | en |
| dc.subject | Carcinoma, Small Cell/*complications/drug therapy | en |
| dc.subject | Etoposide/therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Hypokalemia/*etiology | en |
| dc.subject | Lung Neoplasms/*complications/drug therapy | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Muscle Weakness/*etiology | en |
| dc.title | Severe muscle weakness due to hypokalemia as a manifestation of small-cell carcinoma | en |
| heal.abstract | We describe the case of a 56-year-old man with severe muscle weakness due to heavy hypokalemia (serum potassium 1.44 mmol/l) associated with inappropriate kaliuria and alkalemia. Subsequent investigation revealed the presence of ectopic ACTH hypersecretion due to a small-cell lung carcinoma. A significant clinical/laboratory improvement was achieved following chemotherapy-induced regression of the primary tumor. The profound hypokalemia was probably the result of cortisol hypersecretion, which in concert with the ACTH-induced decreased 11beta-hydroxysteroid dehydrogenase activity can exhibit an increased mineralocorticoid activity. In addition, other ACTH-dependent mineralocorticoids may play a contributory role in the development of severe hypokalemia. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10364746 | - |
| heal.identifier.secondary | http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000029372&Ausgabe=226553&ProduktNr=224278&filename=000029372.pdf | - |
| heal.journalName | Respiration | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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