Association between serum gamma-glutamyltransferase and acute ischemic nonembolic stroke in elderly subjects
Φόρτωση...
Ημερομηνία
Συγγραφείς
Korantzopoulos, P.
Tzimas, P.
Kalantzi, K.
Kostapanos, M.
Vemmos, K.
Goudevenos, J.
Elisaf, M. S.
Milionis, H.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Arch Med Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND AND AIMS: Elevated serum gamma-glutamyltransferase (GGT) levels have been proposed as an independent predictor for cardiovascular morbidity and mortality. The aim of this study was to determine whether GGT levels are associated with acute ischemic/nonembolic stroke in a case-control study of elderly subjects. METHODS: A total of 163 patients >70 years of age (88 men) admitted due to a first-ever acute ischemic/nonembolic stroke and 166 volunteers (87 men) without a history of cardiovascular disease were included. The association between GGT and stroke was determined by multivariate logistic regression modelling after adjusting for potential confounding factors. RESULTS: GGT levels were higher in subjects with metabolic syndrome (MetS) and correlated with MetS individual components including insulin resistance. Stroke patients showed higher concentrations of GGT compared with controls. In univariate analysis, crude odds ratio (OR) for GGT was 1.06/1 IU/L increase (95% CI, 1.03-1.09; p<0.001). Compared to subjects with GGT levels in the lowest quartile, those within the highest quartile had a 4.7-times increase in the odds of experiencing an ischemic stroke (95% CI 2.39-9.11, p<0.001). This association remained significant after controlling for all potential confounders (adjusted OR, 2.90, 95% CI, 1.35-6.27; p=0.007). Analysis of interaction between MetS and GGT showed that subjects with MetS had a 1.08 higher odds/1 IU/L increase in GGT to experience an ischemic stroke [adjusted OR, 1.08 (95% CI, 1.04-1.12; p<0.001). CONCLUSIONS: There are positive associations between serum GGT and first ischemic/nonembolic stroke in individuals >70 years of age independent of established risk factors for cardiovascular disease and concurrent metabolic abnormalities.
Περιγραφή
Λέξεις-κλειδιά
Aged, Aged, 80 and over, *Brain Ischemia/blood/enzymology, Case-Control Studies, Female, Greece, Humans, Male, Odds Ratio, *Stroke/blood/enzymology, gamma-Glutamyltransferase/*blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/20082873
http://ac.els-cdn.com/S0188440909001386/1-s2.0-S0188440909001386-main.pdf?_tid=6bf8c88309eac81f45e030399d8b4b7f&acdnat=1333532656_0ddf158da824db707c1a252749b3dd48
http://ac.els-cdn.com/S0188440909001386/1-s2.0-S0188440909001386-main.pdf?_tid=6bf8c88309eac81f45e030399d8b4b7f&acdnat=1333532656_0ddf158da824db707c1a252749b3dd48
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής