Regeneration of cervix after excisional treatment for cervical intraepithelial neoplasia: a study of collagen distribution
Φόρτωση...
Ημερομηνία
Συγγραφείς
Phadnis, S. V.
Atilade, A.
Bowring, J.
Kyrgiou, M.
Young, M. P.
Evans, H.
Paraskevaidis, E.
Walker, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
BJOG
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To study the distribution of collagen in the regenerated cervical tissue after excisional treatment for cervical intraepithelial neoplasia (CIN). DESIGN: Cohort study. SETTING: A large tertiary teaching hospital in London. POPULATION: Women who underwent repeat excisional treatment for treatment failure or persistent CIN. METHODS: Eligible women who underwent a repeat excisional treatment for treatment failure, including hysterectomy, between January 2002 and December 2007 in our colposcopy unit were identified by the Infoflex((R)) database and SNOMED encoded histopathology database. Collagen expression was assessed using picro-Sirius red stain and the intensity of staining was compared in paired specimens from the first and second treatments. MAIN OUTCOME MEASURE: Differences in collagen expression were examined in the paired excisional treatment specimens. RESULTS: A total of 17 women were included. Increased collagen expression in the regenerated cervical tissue of the second cone compared with the first cone was noted in six women, decreased expression was noted in five women, and the pattern of collagen distribution was equivocal in six women. CONCLUSION: There is no overall change in collagen distribution during regeneration following excisional treatment for CIN.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Cervical Intraepithelial Neoplasia/metabolism/*surgery, Cervix Uteri/metabolism/*physiology, Cohort Studies, Collagen/*metabolism, Electrosurgery/*methods, Female, Humans, Middle Aged, Neoplasm Recurrence, Local/metabolism/surgery, Regeneration/*physiology, Reoperation, Uterine Cervical Neoplasms/metabolism/*surgery
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21895948
http://onlinelibrary.wiley.com/store/10.1111/j.1471-0528.2011.03085.x/asset/j.1471-0528.2011.03085.x.pdf?v=1&t=h0p6qvuo&s=dc0583b7e8d8f816bb7c777a0b67456bf7b88d64
http://onlinelibrary.wiley.com/store/10.1111/j.1471-0528.2011.03085.x/asset/j.1471-0528.2011.03085.x.pdf?v=1&t=h0p6qvuo&s=dc0583b7e8d8f816bb7c777a0b67456bf7b88d64
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής