First-trimester ductus venosus screening for cardiac defects: a meta-analysis
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
BJOG
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Heart defects are the most common congenital abnormalities. OBJECTIVE: We aimed to evaluate in a meta-analysis the screening performance of abnormal ductus venosus (DV) Doppler waveform for detection of congenital heart disease (CHD) in chromosomally normal fetuses. SEARCH STRATEGY: Studies were retrieved from a search of MEDLINE, ISI, SCOPUS and EMBASE (from 1999 to March 2011) using the keywords 'ductus venosus', 'DV', 'chromosomal abnormalities', 'congenital heart disease' and 'nuchal translucency'. SELECTION CRITERIA: We considered all studies that examined the diagnostic performance of DV in the first trimester for CHD in chromosomally normal fetuses. We included studies that were limited to fetuses with increased nuchal translucency (NT), normal NT, and studies that examined fetuses regardless of NT status. DATA COLLECTION AND ANALYSIS: Seven studies (n = 50,354) regardless of the NT status, nine studies (n = 2908) with increased NT and seven studies (n = 47,610) with normal NT were included in the meta-analysis. We drew hierarchical summary receiver operating characteristic (HSROC) curves using the parameters of the fitted models. MAIN RESULTS: In populations including participants regardless of NT status, the summary sensitivity and specificity of DV for detecting CHD were 50 and 93%, respectively. In participants with increased NT, the summary sensitivity and specificity were 83 and 80%, and in those with normal NT, they were 19 and 96%, respectively. AUTHORS' CONCLUSIONS: The estimated performance of DV assessment for detection of CHD in chromosomally normal fetuses can be considered in evaluating the potential use and limitations of this screening test.
Περιγραφή
Λέξεις-κλειδιά
Female, Fetal Heart/abnormalities/*ultrasonography, Heart Defects, Congenital/embryology/*ultrasonography, Humans, Nuchal Translucency Measurement, Pregnancy, Pregnancy Trimester, First, Sensitivity and Specificity, *Ultrasonography, Prenatal
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21668765
http://onlinelibrary.wiley.com/store/10.1111/j.1471-0528.2011.03029.x/asset/j.1471-0528.2011.03029.x.pdf?v=1&t=h0l47h33&s=705dc5c0b84308ad3f25b0db2bc4fa174a8e7b05
http://onlinelibrary.wiley.com/store/10.1111/j.1471-0528.2011.03029.x/asset/j.1471-0528.2011.03029.x.pdf?v=1&t=h0l47h33&s=705dc5c0b84308ad3f25b0db2bc4fa174a8e7b05
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής