Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2

dc.contributor.authorSzabo, P.en
dc.contributor.authorPanneerselvam, C.en
dc.contributor.authorClinton, M.en
dc.contributor.authorFrangou-Lazaridis, M.en
dc.contributor.authorWeksler, D.en
dc.contributor.authorWhittington, E.en
dc.contributor.authorMacera, M. J.en
dc.contributor.authorGrzeschik, K. H.en
dc.contributor.authorSelvakumar, A.en
dc.contributor.authorHorecker, B. L.en
dc.date.accessioned2015-11-24T18:55:51Z
dc.date.available2015-11-24T18:55:51Z
dc.identifier.issn0340-6717-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18940
dc.rightsDefault Licence-
dc.subjectBase Sequenceen
dc.subject*Chromosomes, Human, Pair 2en
dc.subjectCloning, Molecularen
dc.subjectDeoxyribonuclease BamHIen
dc.subjectHumansen
dc.subjectMolecular Sequence Dataen
dc.subjectNucleic Acid Hybridizationen
dc.subjectPolymorphism, Geneticen
dc.subjectPromoter Regions, Geneticen
dc.subjectProtein Precursors/*geneticsen
dc.subjectRepetitive Sequences, Nucleic Aciden
dc.subjectSequence Analysis, DNAen
dc.subjectThymosin/*analogs & derivatives/geneticsen
dc.titleProthymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2en
heal.abstractA genomic clone encoding prothymosin alpha (gene symbol: PTMA), a nuclear-targeted protein associated with cell proliferation, was isolated and the 5'-regulatory region subcloned and sequenced. Because of previously reported discrepancies between several cDNA clones and a genomic clone for prothymosin alpha, we determined the sequence of the first exon and of a 1.7-kb region 5' to the first exon. The sequence of the genomic clone reported here corresponds to the published cDNA sequences, suggesting that the previously noted discrepancies may be due to genetic polymorphism in this region. In addition, our sequence data extend the known 5'-upstream sequence by an additional 1.5 kb allowing the identification of numerous, potential cis-acting regulatory sites. This 5'-flanking cloned probe permitted us to localize the prothymosin gene to chromosome 2 in humans.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7916742-
heal.journalNameHum Geneten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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