Prospective randomized trial of external versus internal transcatheter cardioversion in patients with chronic atrial fibrillation
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Authors
Paravolidakis, K. E.
Kolettis, T. M.
Theodorakis, G. N.
Paraskevaidis, I. A.
Apostolou, T. S.
Kremastinos, D. T.
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peer-reviewed
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J Interv Card Electrophysiol
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Description
To evaluate the safety and long-term efficacy of internal transcatheter cardioversion, forty patients with chronic, lone atrial fibrillation were studied. The patients were randomised to internal transcatheter cardioversion or to conventional external cardioversion. In cases where the procedure was unsuccessful, cross-over to the alternate method was performed. Oral anticoagulation therapy was started three weeks prior to the procedure and was maintained for another three weeks following successful cardioversion. Sinus rhythm was restored in 16/18 patients (88%) in the internal cardioversion group, versus 9/22 patients (40%) in the external cardioversion group (p < 0.01). In addition, 8/13 (61%) patients who were crossed-over to internal cardioversion were successfully cardioverted to sinus rhythm. In contrast, both patients who were crossed-over to external cardioversion remained in atrial fibrillation. During a mean follow-up period of 23 months, 13 (39.3%) patients maintained sinus rhythm. Using the intention to treat principle, the recurrence rate was not statistically different between the two methods. It is concluded that internal cardioversion is more effective in acutely restoring sinus rhythm compared to external cardioversion. However, both methods have similar long-term recurrence rates.
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Keywords
Atrial Fibrillation/physiopathology/*therapy/ultrasonography, Chronic Disease, Echocardiography, Transesophageal, Electric Countershock/*methods, Electrocardiography, Female, Follow-Up Studies, *Heart Catheterization, Humans, Male, Middle Aged, Prospective Studies, Recurrence, Treatment Outcome
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http://www.ncbi.nlm.nih.gov/pubmed/9870019
http://www.springerlink.com/content/tn334143u0661j45/fulltext.pdf
http://www.springerlink.com/content/tn334143u0661j45/fulltext.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής