The effect of exogenous surfactant in patients with lung contusions and acute lung injury
Φόρτωση...
Ημερομηνία
Συγγραφείς
Tsangaris, I.
Galiatsou, E.
Kostanti, E.
Nakos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Intensive Care Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To investigate the acute effect of surfactant replacement in multiple-trauma patients with lung contusion and acute lung injury. DESIGN AND SETTING: Prospective randomized clinical trial in the 14-bed ICU of a 750-bed university hospital. PATIENTS AND PARTICIPANTS: Sixteen ventilated trauma patients with severe refractory hypoxemia (PaO(2)/FIO(2)<150 mmHg) and lung contusions. INTERVENTIONS: Patients were randomly assigned to either surfactant administration (n=8) or standard treatment (n=8). A single dose of natural bovine surfactant was instilled bronchoscopically in the involved lung areas; each segmental bronchus received (200/19) mg/kg body weight. MEASUREMENTS AND RESULTS: The surfactant group demonstrated an acute improvement in oxygenation after surfactant replacement compared both to control group and to baseline values. In the surfactant group PaO(2)/FIO(2) increased from 100+/-20 mmHg at baseline to 140+/-20 (6 h), 163+/-26 (12 h), and 187+/-30 mmHg (24h). Compliance increased from 30 to 36 ml/cmH(2)O at 6 h after administration, and this increase remained significant at the 24, 48, and 72 h time points. The surfactant group demonstrated a higher response to recruitment maneuvers than the control group at 6 h. The mean duration of ventilatory support was 5.6 +/-2.6 days in the surfactant group and 8.1+/-2.4 days in the control group. CONCLUSIONS: Surfactant replacement was well tolerated in patients with lung contusions and severe hypoxemia and resulted in improved oxygenation and compliance.
Περιγραφή
Λέξεις-κλειδιά
Apache, Adult, Anoxia/*therapy, Humans, Injury Severity Score, Middle Aged, Pulmonary Gas Exchange, Respiration, Artificial, Respiratory Distress Syndrome, Adult/classification/*therapy, Surface-Active Agents/*therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17377767
http://www.springerlink.com/content/xu02567106084315/fulltext.pdf
http://www.springerlink.com/content/xu02567106084315/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής