Prospective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastases

Απλή σελίδα τεκμηρίου
dc.contributor.authorPamecha, V.en
dc.contributor.authorNedjat-Shokouhi, B.en
dc.contributor.authorGurusamy, K.en
dc.contributor.authorGlantzounis, G. K.en
dc.contributor.authorSharma, D.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T18:56:00Z
dc.date.available2015-11-24T18:56:00Z
dc.identifier.issn1421-9883-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18967
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/therapeutic useen
dc.subjectChemotherapy, Adjuvanten
dc.subjectColorectal Neoplasms/*pathology/*therapyen
dc.subject*Embolization, Therapeuticen
dc.subjectFemaleen
dc.subjectHepatectomy/*methodsen
dc.subjectHumansen
dc.subjectLiver Neoplasms/*secondary/surgery/*therapyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Portal Veinen
dc.subjectProspective Studiesen
dc.subjectSurvival Analysisen
dc.subjectTreatment Outcomeen
dc.titleProspective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastasesen
heal.abstractBACKGROUND: Liver resection is contraindicated in patients with multiple bilobar colorectal liver metastases because of the small liver remnant. An alternative strategy which may be curative is a two-stage hepatectomy in which the cancer is resected from one lobe and regeneration allowed prior to contralateral lobe resection. OBJECTIVE: To assess the feasibility, risks, and outcomes in a prospectively applied strategy for two-stage hepatectomy. METHODS: Over a 6-year period, 14 of 280 patients undergoing liver resection for colorectal liver metastases (5%) were considered for two-stage hepatectomy. Surgery was combined with chemotherapy in all (n = 14) and portal vein embolisation (PVE) selectively (n = 5). Median follow-up was 43 months. RESULTS: Both stages were completed in 11 of 14 patients (78%). There were no deaths. Post-operative complication rates were 0% (1st hepatectomy) and 27% (2nd hepatectomy). The 5-year survival after the second hepatectomy was 50%. The mean disease-free survival was 25 +/- 7.5 months. CONCLUSION: Two-stage hepatectomy combined with systemic chemotherapy and PVE can produce long-term survival in patients with multiple bilobar colorectal liver metastases.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1159/000176063-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19033722-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000176063&Ausgabe=240353&ProduktNr=223996&filename=000176063.pdf-
heal.journalNameDig Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ