Individual responses to novelty are associated with differences in behavioral and neurochemical profiles
Φόρτωση...
Ημερομηνία
Συγγραφείς
Antoniou, K.
Papathanasiou, G.
Papalexi, E.
Hyphantis, T.
Nomikos, G. G.
Spyraki, C.
Papadopoulou-Daifoti, Z.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Behav Brain Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Experimental animals can be differentiated on the basis of their horizontal or vertical activity to high responders (HR) and low responders (LR) upon exposure to a novel environment. These individual differences have been associated with behavioral and neurobiological differences in a number of experimental procedures used for studying sensitivity to psychostimulants, anxiety, depression, and cognitive function. In the present study, we differentiated the rats to HR and LR based on their vertical activity upon exposure to a novel environment. Additionally, we ascertained whether HR and LR rats differ in a battery of tests such as passive avoidance (PA), object recognition (OR), and the water-maze (WM) that provide indices for cognitive function and the forced swim test (FST), an animal model of affective responsivity and antidepressant-like activity. Potential differences in neurochemical indices between the two phenotypes were also examined. HR rats displayed impaired non-spatial object recognition memory, but enhanced spatial performance, as compared to LR rats. FST induced "depressive-like" symptoms in both phenotypes that were differently manifested in HR versus LR rats. Neurochemical findings revealed distinct differences in serotonergic and dopaminergic activity in the striatum and the prefrontal cortex of HR as compared to LR rats. The above results show that HR and LR rats exhibit important differences in a battery of tests related to cognitive performance or affective responsivity, which may be associated with differences in certain neurobiological parameters.
Περιγραφή
Λέξεις-κλειδιά
Analysis of Variance, Animals, Avoidance Learning/physiology, Depression/metabolism, Dopamine/*metabolism, Exploratory Behavior/*physiology, Individuality, Male, Maze Learning/*physiology, Memory/physiology, Motor Activity/*physiology, Neostriatum/metabolism, Phenotype, Prefrontal Cortex/metabolism, Rats, Rats, Wistar, Recognition (Psychology)/*physiology, Serotonin/*metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18036673
http://ac.els-cdn.com/S016643280700544X/1-s2.0-S016643280700544X-main.pdf?_tid=7c346b7c1aa48e8f52437fd1053b868b&acdnat=1332942726_54bc2dbee8fdb63bb7e49c8a2ce7acaf
http://ac.els-cdn.com/S016643280700544X/1-s2.0-S016643280700544X-main.pdf?_tid=7c346b7c1aa48e8f52437fd1053b868b&acdnat=1332942726_54bc2dbee8fdb63bb7e49c8a2ce7acaf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής