Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer
Φόρτωση...
Ημερομηνία
Συγγραφείς
Ioachim, E.
Tsanou, E.
Briasoulis, E.
Batsis, C.
Karavasilis, V.
Charchanti, A.
Pavlidis, N.
Agnantis, N. J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Breast
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. Archived material of paraffin-embedded breast carcinoma tissues from a cohort of 134 patients with primary invasive breast cancer was used. Hsp27 and pS2 (>10% of tumor cells stained) were found to be expressed in 63.6% and 37.6% of cases, respectively, and were correlated negatively with grading (P=0.006 and 0.01) and positively with estrogen receptors (ER) (P=0.04 and 0.04). pS2 expression was correlated with lymph node status (P=0.02), tumor size (P=0.01), progesterone receptor (PR) content (P=0.02), hsp27 (P=0.015) and bcl-2 protein (P=0.001). An inverse relationship between pS2 expression and the expression of p53 protein (P=0.005) and proliferation-associated index MIB1 (P<0.0001) was noted. Stromal cathepsin D was positively correlated with tumor grade (P=0.01), PCNA (P=0.007), MIB1 (P=0.001) and p53 (P=0.01), and negatively with ER (P=0.04) and bcl-2 (P<0.0001). MT was correlated positively with stromal CD (P=0.007) and inversely with PgR (P=0.04). Univariate analysis showed CD expression to be a positive prognostic factor for survival (P=0.035), with borderline significance, while MT was more strongly positive (P=0.01). However, none of the proteins studied was found to be related to disease outcome in univariate analysis. Our data show that hsp27, pS2 and stromal CD expression may reflect tumor differentiation and the functional status of ER in breast cancer, but stromal CD and tumor MT expression were the only factors found that may be of limited prognostic value.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Analysis of Variance, Biopsy, Needle, Breast Neoplasms/metabolism/*pathology, Carcinoma, Ductal, Breast/metabolism/mortality/pathology, Cathepsin D/analysis/*metabolism, Chi-Square Distribution, Cohort Studies, Female, Heat-Shock Proteins/analysis/*metabolism, Humans, Immunohistochemistry, Metallothionein/analysis/*metabolism, Middle Aged, Neoplasm Invasiveness/pathology, Neoplasm Proteins/analysis/metabolism, Probability, Prognosis, Proteins/analysis/*metabolism, Sensitivity and Specificity, Survival Analysis, Tumor Markers, Biological/*analysis, Tumor Suppressor Protein p53/analysis, Tumor Suppressor Proteins
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/14659340
http://ac.els-cdn.com/S0960977602002904/1-s2.0-S0960977602002904-main.pdf?_tid=bed18a7190bd1a41ebe58f8302393532&acdnat=1333703235_ce4b2c2a29dad68d4533fe6eb5c291b5
http://ac.els-cdn.com/S0960977602002904/1-s2.0-S0960977602002904-main.pdf?_tid=bed18a7190bd1a41ebe58f8302393532&acdnat=1333703235_ce4b2c2a29dad68d4533fe6eb5c291b5
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής