In vitro effects of hormones and autacoids on the activity of acid phosphatase in the lysates of endotoxin-activated rat peritoneal and bronchoalveolar macrophages

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dc.contributor.authorKondomerkos, D. J.en
dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorKotoulas, O. B.en
dc.date.accessioned2015-11-24T19:11:15Z
dc.date.available2015-11-24T19:11:15Z
dc.identifier.issn0213-3911-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20911
dc.rightsDefault Licence-
dc.subjectAcid Phosphatase/antagonists & inhibitors/*metabolismen
dc.subjectAnimalsen
dc.subjectAutacoids/*pharmacologyen
dc.subjectCells, Cultureden
dc.subjectColoring Agentsen
dc.subjectCulture Mediaen
dc.subjectCyclic AMP/physiologyen
dc.subjectEndotoxins/*pharmacologyen
dc.subjectEnzyme Inhibitors/pharmacologyen
dc.subjectFemaleen
dc.subjectHematoxylinen
dc.subjectHormones/*pharmacologyen
dc.subjectHydrogen Peroxide/metabolismen
dc.subjectLipopolysaccharides/pharmacologyen
dc.subjectMacrophage Activation/drug effectsen
dc.subjectMacrophages, Alveolar/drug effects/*enzymology/ultrastructureen
dc.subjectMacrophages, Peritoneal/drug effects/*enzymology/ultrastructureen
dc.subjectMaleen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectType C Phospholipases/physiologyen
dc.titleIn vitro effects of hormones and autacoids on the activity of acid phosphatase in the lysates of endotoxin-activated rat peritoneal and bronchoalveolar macrophagesen
heal.abstractPeritoneal and bronchoalveolar macrophages activated in vitro by endotoxin, exhibit alterations in the acid phosphatase activity of cell lysates when certain hormones or autacoids are present in the culture medium. They also show morphological changes concerning general appearance and acid phosphatase cytochemistry. Certain agents known to increase the intracellular levels of cyclic AMP, such as dopamine and prostaglandin E2, decreased this enzyme activity in the lysates of peritoneal macrophages. Adrenalin had no effect on this activity at 14 hours, but was found to increase the activity in the culture medium at the initial hours of incubation. Glucagon decreased whereas insulin increased acid phosphatase activity in bronchoalveolar macrophages. Serotonin or histamine, known to activate phospholipase C, increased this activity in peritoneal or bronchoalveolar macrophages. The results of this study, taken together with previously published data (Kondomerkos et al., 2003), suggest that hormones and autacoids may control certain parameters of macrophage activation including acid phosphatase activity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12973679-
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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