Evidence that D-glucaro-1,4-lactone shortens the pharmacological action of drugs being disposed via the bile as glucuronides

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Marselos, M.
Dutton, G.
Hanninen, O.

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peer-reviewed

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Biochem Pharmacol

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Animals, Bile/*metabolism, Depression, Chemical, Drug Interactions, Glucaric Acid/analogs & derivatives/*pharmacology, Glucuronates/*metabolism, Glucuronidase/metabolism, Intestines/enzymology, Lactones/pharmacology, Male, Mice, Motor Activity/drug effects, Pharmaceutical Preparations/*metabolism, Phenobarbital/metabolism/pharmacology, Progesterone/metabolism/pharmacology, Rats, Rats, Inbred Strains, Sugar Acids/*pharmacology, Zoxazolamine/pharmacology

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http://www.ncbi.nlm.nih.gov/pubmed/1191334
http://ac.els-cdn.com/0006295275904037/1-s2.0-0006295275904037-main.pdf?_tid=ed3f70491513aab5543d63e57898aeb3&acdnat=1332744073_38d50629bed337aeed417dd315458dde

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en

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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής

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