Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome

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dc.contributor.authorLazaros, L.en
dc.contributor.authorMarkoula, S.en
dc.contributor.authorXita, N.en
dc.contributor.authorGiannopoulos, S.en
dc.contributor.authorGogou, P.en
dc.contributor.authorLagos, G.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorGeorgiou, I.en
dc.date.accessioned2015-11-24T19:34:52Z
dc.date.available2015-11-24T19:34:52Z
dc.identifier.issn1600-0404-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23659
dc.rightsDefault Licence-
dc.subjectAge of Onseten
dc.subjectAgeden
dc.subjectBlood Glucose/metabolismen
dc.subjectBrain/pathology/radiographyen
dc.subjectDyslipidemias/diagnosis/epidemiologyen
dc.subjectElectrocardiographyen
dc.subjectEstrogen Receptor alpha/*geneticsen
dc.subjectFemaleen
dc.subjectGene Expression/*geneticsen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectHypertension/diagnosis/epidemiologyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/diagnosis/*epidemiology/metabolismen
dc.subjectMiddle Ageden
dc.subjectObesity/diagnosis/epidemiologyen
dc.subject*Polymorphism, Geneticen
dc.subjectStroke/diagnosis/*epidemiology/*geneticsen
dc.subjectTomography, X-Ray Computeden
dc.titleAssociation of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndromeen
heal.abstractOBJECTIVE: The vascular protective effects of estrogens are mediated by their binding to the two known estrogen receptors. In this study, we examine the association of stroke with two common polymorphisms of the ESR1 gene in patients with metabolic syndrome. MATERIALS AND METHODS: DNA from 130 patients hospitalized for ischemic stroke and 240 healthy controls were genotyped for ESR1 PvuII and XbaI polymorphisms. Results - Comparing female and male patients, it was found that CCGG diplotype is more frequent in male patients (P = 0.03). In addition, the AA genotype is associated with the onset of stroke at a younger age in the male patient group (P < 0.05). CONCLUSIONS: These findings suggest that PvuII and XbaI polymorphisms may affect the age at onset of the first stroke and the probability of developing cerebrovascular disease.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1600-0404.2007.00926.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17854418-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1600-0404.2007.00926.x/asset/j.1600-0404.2007.00926.x.pdf?v=1&t=h0b2c2q5&s=1e2db5e949f09ceb113184541820f693c85cc1b2-
heal.journalNameActa Neurol Scanden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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