The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype

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dc.contributor.authorBoot-Handford, R. P.en
dc.contributor.authorMichaelidis, T. M.en
dc.contributor.authorHillarby, M. C.en
dc.contributor.authorZambelli, A.en
dc.contributor.authorDenton, J.en
dc.contributor.authorHoyland, J. A.en
dc.contributor.authorFreemont, A. J.en
dc.contributor.authorGrant, M. E.en
dc.contributor.authorWallis, G. A.en
dc.date.accessioned2015-11-24T16:31:52Z
dc.date.available2015-11-24T16:31:52Z
dc.identifier.issn0959-9673-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7490
dc.rightsDefault Licence-
dc.subjectbcl-2en
dc.subjectbcl-2 knockout mouseen
dc.subjectgrowth plateen
dc.subjectosteoblasten
dc.subjectboneen
dc.subjectcollagenen
dc.subjecthormone-related peptideen
dc.subjectcell-cycle entryen
dc.subjectparathyroid-hormoneen
dc.subjectskeletal developmenten
dc.subjecttargeted disruptionen
dc.subjectindian hedgehogen
dc.subjectb-cellsen
dc.subjectcartilageen
dc.subjectmiceen
dc.subjectexpressionen
dc.titleThe bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotypeen
heal.abstractHistological examination of long bones from 1-day-old bcl-2 knockout and age-matched control mice revealed no obvious differences in length of bone, growth plate architecture or stage of endochondral ossification. In 35-day-old bcl-2 knockout mice that are growth retarded or 'dwarfed', the proliferative zone of the growth plate appeared slightly thinner and the secondary centres of ossification less well developed than their age-matched wild-type controls. The most marked histological effects of bcl-2 ablation were on osteoblasts and bone. 35-day-old knockout mouse bones exhibited far greater numbers of osteoblasts than controls and the osteoblasts had a cuboidal phenotype in comparison with the normal flattened cell appearance. In addition, the collagen deposited by the osteoblasts in the bcl-2 knockout mouse bone was disorganized in comparison with control tissue and had a pseudo-woven appearance. The results suggest an important role for Bcl-2 in controlling osteoblast phenotype and bone deposition in vivo.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000076792900008-
heal.journalNameInternational Journal of Experimental Pathologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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