Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia

Απλή σελίδα τεκμηρίου
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorKarabina, S. A. P.en
dc.contributor.authorTambaki, A. P.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorMiltiadous, G.en
dc.contributor.authorGoudevenos, J. A.en
dc.contributor.authorCariolou, M. A.en
dc.contributor.authorChapman, M. J.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M.en
dc.date.accessioned2015-11-24T16:46:29Z
dc.date.available2015-11-24T16:46:29Z
dc.identifier.issn0022-2275-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9076
dc.rightsDefault Licence-
dc.subjectfamilial hypercholesterolemiaen
dc.subjectlow density lipoproteinen
dc.subjectlipoprotein subspeciesen
dc.subjecthigh density lipoproteinen
dc.subjectpaf-acetylhydrolaseen
dc.subjectpolygenic hypercholesterolemiaen
dc.subjectlow-density-lipoproteinen
dc.subjectheterozygous familial hypercholesterolemiaen
dc.subjectcoronary-artery diseaseen
dc.subjectpaf-acetylhydrolaseen
dc.subjecthuman-plasmaen
dc.subjectoxidative susceptibilityen
dc.subjectphospholipase a(2)en
dc.subjectatherosclerosisen
dc.subjectidentificationen
dc.subjectdegradationen
dc.titleAltered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemiaen
heal.abstractPlatelet-activating factor-acetylhydrolase (PAF-AH) is a lipoprotein-associated phospholipase A(2) capable of hydrolyzing platelet-activating factor (PAF) and oxidatively modified phospholipids. We studied the plasma- and lipoprotein-associated PAF-AH activity in patients with primary hypercholesterolemia. Thirty-eight unrelated patients with heterozygous familial hypercholesterolemia (HeteroFH), five patients with homozygous FH (HomoFH), and 33 patients with primary non-FH hypercholesterolemia (NonFH) participated in the study. In all patient groups the plasma PAF-AH activity was significantly elevated compared with 33 normolipidemic controls, the HomoFH having the highest and the NonFH patients showing the lowest enzyme activity. Gradient ultracentrifugation studies showed that this increase is not only due to the elevation in the plasma LDL but also to the increase in the PAF-AH activity associated with each LDL subfraction, being more profound in the small-dense LDL-5. Unlike LDL, no difference in the HDL-associated PAF-AH activity was observed among all groups. Consequently, an altered distribution of enzyme activity among apolipoprotein B (apoB)- and apolipoprotein A-I (ApoA-I)-containing lipoproteins is observed in hypercholesterolemic patients, resulting in a significant decrease in the ratio of the HDL-associated PAF-AH to the total plasma enzyme activity compared with controls. This reduction is proportional to the increase of the plasma LDL-cholesterol (LDL-C) levels and consequently to the severity of the hypercholesterolemia. Thus, the ratio of HDL-associated PAF-AH-total plasma enzyme activity may be useful as a potential marker of atherogenicity in subjects with primary hypercholesterolemia.-Tsimihodimos, V ., S-A. P. Karabina,A. P. Tambaki, E. Bairaktari, G. Miltiadous, J. A. Goudevenos, M. A. Cariolou, M.J. Chapman, A. D. Tselepis, and M. Elisaf. Altered distribution of platelet-activating factor-acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000174102900009-
heal.identifier.secondaryhttp://www.jlr.org/content/43/2/256.full.pdf-
heal.journalNameJournal of Lipid Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2002-
heal.publisherLipid Research Inc.en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ