Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer Lett
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Lysosomal proteinases, cathepsin B (CB) and cathepsin D (CD) have been implicated in the progression of several human tumors. In the present study, the antigen levels of CB and CD, and their immunohistochemical staining were compared in paired colorectal tumors (n =64) and background colon tissue of the same patients with clinicopathological staging. The antigen levels, were found to be significantly higher in cancer tissue (mean 35.79 ng/mg protein for CB and 3.97 ng/mg protein for CD) than in corresponding normal mucosa (24.62 ng/mg protein for CB and 2.69 ng/mg protein for CD). CB antigen levels were positively correlated with differentiation grade and Duke's stage (P < 0.001 and P = 0.041, respectively), but not correlated with nodal status. CD antigen levels were not correlated with the previous parameters. Staining intensity for both antigens increased from adenoma to adenocarcinoma. The degree of staining for CB and CD was associated with differentiation grade (P = 0.004 and 0.001, respectively), Dukes' stage (P = 0.002 and 0.001, respectively) and lymph node involvement (P = 0.002 and P < 0.001, respectively).
Περιγραφή
Λέξεις-κλειδιά
Adenoma/metabolism/*pathology, Adult, Aged, Aged, 80 and over, Carcinoma/metabolism/*pathology, Cathepsin B/*biosynthesis, Cathepsin D/*biosynthesis, Colon/metabolism, Colorectal Neoplasms/metabolism/*pathology, Disease Progression, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Invasiveness/pathology, Tumor Markers, Biological
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15036666
http://ac.els-cdn.com/S0304383503006888/1-s2.0-S0304383503006888-main.pdf?_tid=ad639eabb9548a4dc40b2e654ed610dc&acdnat=1336119678_357317b00a86b6d4b008bd5022b84cfe
http://ac.els-cdn.com/S0304383503006888/1-s2.0-S0304383503006888-main.pdf?_tid=ad639eabb9548a4dc40b2e654ed610dc&acdnat=1336119678_357317b00a86b6d4b008bd5022b84cfe
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής