Improved left ventricular relaxation during short-term right ventricular outflow tract compared to apical pacing

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dc.contributor.authorKolettis, T. M.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorTsiapras, D.en
dc.contributor.authorPopov, T.en
dc.contributor.authorParaskevaides, I. A.en
dc.contributor.authorKremastinos, D. T.en
dc.date.accessioned2015-11-24T19:11:25Z
dc.date.available2015-11-24T19:11:25Z
dc.identifier.issn0012-3692-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20926
dc.rightsDefault Licence-
dc.subjectBundle of His/physiologyen
dc.subjectCardiac Outputen
dc.subject*Cardiac Pacing, Artificialen
dc.subjectEchocardiography, Doppleren
dc.subjectElectrocardiographyen
dc.subjectFemaleen
dc.subjectHeart Catheterizationen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Contractionen
dc.subjectPurkinje Fibers/physiologyen
dc.subjectSupine Positionen
dc.subject*Ventricular Functionen
dc.subject*Ventricular Function, Leften
dc.subjectVentricular Pressureen
dc.titleImproved left ventricular relaxation during short-term right ventricular outflow tract compared to apical pacingen
heal.abstractSTUDY OBJECTIVES: Pacing-induced asynchrony may deteriorate left ventricular function; however, limited data exists in humans. The aim of our study was to compare left ventricular hemodynamics during short-term atrioventricular sequential pacing from the right ventricular apex and from the outflow tract of the right ventricle. DESIGN: Three 5-min pacing intervals were applied in a random order, at a rate of 15 beats/min above the resting sinus rate. Atrioventricular sequential pacing from the two sites was compared with atrial pacing. During each pacing mode, left ventricular pressure was recorded, and cardiac output was calculated using Doppler echocardiography. SETTING: Cardiac catheterization laboratory. PATIENTS: Twenty patients (18 male, mean age 62 +/- 11 years) without structural heart disease were studied. RESULTS: During atrial pacing, maximum negative first derivative of pressure (dp/dt) was 1,535 +/- 228 mm Hg/s; during pacing from the apex it decreased to 1,221 +/- 294 mm Hg/s (p = 0.0001), but was not significantly different during pacing from the outflow tract (1,431 +/- 435 mm Hg/s, p > 0.05). Isovolumic relaxation time constant (tau) during atrial pacing was 39.7 +/- 11.9 ms; during pacing from the apex, it increased to 47.9 +/- 14.0 (p = 0.001), but was not significantly different during pacing from the outflow tract (42.5 +/- 11.2, p > 0.05). Peak systolic pressure decreased significantly during atrioventricular sequential pacing from either site; however, it did not differ between the two sites. No differences in end-diastolic pressure, maximum positive dp/dt, or cardiac output could be demonstrated. CONCLUSION: In patients with no structural heart disease, short-term right ventricular outflow tract pacing is associated with more favorable diastolic function, compared to right ventricular apical pacing.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10631200-
heal.identifier.secondaryhttp://chestjournal.chestpubs.org/content/117/1/60.full.pdf-
heal.journalNameChesten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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