Use of mycophenolate mofetil in the experimental allo-transplantation of hepatocytes in rats with fulminant hepatic failure

Απλή σελίδα τεκμηρίου
dc.contributor.authorKontalexis, S.en
dc.contributor.authorPapalois, A.en
dc.contributor.authorBibidakis, E.en
dc.contributor.authorGravvanis, A.en
dc.contributor.authorLykoudis, E.en
dc.contributor.authorTheodossopoulou, E.en
dc.contributor.authorDimitroulopoulos, D.en
dc.contributor.authorSfiniadakis, I.en
dc.contributor.authorPrachalias, A.en
dc.contributor.authorFelekouras, E.en
dc.contributor.authorDedeilias, P.en
dc.contributor.authorKontogiorgi, M.en
dc.contributor.authorPapadimitriou, L.en
dc.contributor.authorPapadimitriou, I.en
dc.date.accessioned2015-11-24T18:55:19Z
dc.date.available2015-11-24T18:55:19Z
dc.identifier.issn0041-1345-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18854
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCyclosporine/therapeutic useen
dc.subjectHepatocytes/*transplantationen
dc.subjectLiver Failure, Acute/*therapyen
dc.subjectMycophenolic Acid/*analogs & derivatives/*therapeutic useen
dc.subjectRatsen
dc.subjectRats, Inbred Lewen
dc.subjectRats, Wistaren
dc.subjectTransplantation, Homologous/immunologyen
dc.titleUse of mycophenolate mofetil in the experimental allo-transplantation of hepatocytes in rats with fulminant hepatic failureen
heal.abstractAIM: The aim of the study was to evaluate the beneficial effect of mycophenolate mofetil (MMF) as an immunosuppressive agent for experimental transplantation of hepatocytes in rats with fulminant hepatic failure (FHF). MATERIALS AND METHODS: Six Wistar rats were used as donors and 40 Lewis rats at recipients, including four groups of 10 animals each. Group A received no treatment; Group B, cyclosporine (20 mg/kg days 0-5 and 10 mg/kg days 6-15); Group C, MMF (12 mg/kg per os every day); and Group D, MMF (23 mg/kg per os every day). Hepatocytes were transplanted intrasplenically. Animals were followed for 15 days. RESULTS: The survival rates for Group A were maximum 72 h, whereas Groups B, C, and D showed 50%, 70%, and 80%, respectively. Biochemical evaluation and histology showed satisfactory function and engraftment, respectively. CONCLUSION: The use of MMF in this experimental model yielded safe, satisfactory immunosuppression especially at the dose of 23 mg/kg.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.transproceed.2004.06.011-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15350466-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0041134504006761/1-s2.0-S0041134504006761-main.pdf?_tid=7ef9662782463b0a868e7609dea9c702&acdnat=1333466363_8efceb4be1d59f2517b9e71e601f7ed3-
heal.journalNameTransplant Procen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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