An electron microscopic study of collagen fibril structure after lithium treatment--I. The effect of different lithium doses on mouse skin collagen
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kounadi, E.
Tzaphlidou, M.
Glaros, D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Micron
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The structure of mouse skin collagen fibrils after treatment with lithium chloride at doses of 1.5 and 6 meq/kg of body weight was studied by electron microscopy. Animals were sacrificed 1 day, 1, 2 and 6 months after the end of a 30 consecutive days experimental period. With the first dose, which is commonly used clinically, although there were areas with normal collagen fibrils there were also regions where the characteristic parallel packing of fibrils was lost completely or it was preserved for a part of the area. With high doses, in most regions the normal packing of fibrils was replaced by an anarchic arrangement. In both cases, collagen fibrils had a marked decrease in mean diameter and showed a higher degree of variability in width and shape than collagen fibrils from controls. Also, many clusters of abnormal fibrils were found with a diameter of up to 260 nm vs 109 nm and a highly irregular outline when viewed in cross-sections. The periodicity D as well as the banding pattern were normal.
Περιγραφή
Λέξεις-κλειδιά
Animals, Collagen/*drug effects/ultrastructure, Dose-Response Relationship, Drug, Lithium Chloride/*pharmacology/toxicity, Male, Mice, Microscopy, Electron, Skin/chemistry/drug effects
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8069614
http://ac.els-cdn.com/0968432894900280/1-s2.0-0968432894900280-main.pdf?_tid=9bdae67ccdebb4a9cfc695ea87cc2e06&acdnat=1336114558_8596e7fcda4f278a67f6fb39c3cd485d
http://ac.els-cdn.com/0968432894900280/1-s2.0-0968432894900280-main.pdf?_tid=9bdae67ccdebb4a9cfc695ea87cc2e06&acdnat=1336114558_8596e7fcda4f278a67f6fb39c3cd485d
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής