Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis

dc.contributor.authorFotsis, T.en
dc.contributor.authorPepper, M. S.en
dc.contributor.authorAktas, E.en
dc.contributor.authorBreit, S.en
dc.contributor.authorRasku, S.en
dc.contributor.authorAdlercreutz, H.en
dc.contributor.authorWahala, K.en
dc.contributor.authorMontesano, R.en
dc.contributor.authorSchweigerer, L.en
dc.date.accessioned2015-11-24T19:15:42Z
dc.date.available2015-11-24T19:15:42Z
dc.identifier.issn0008-5472-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21545
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAnticarcinogenic Agents/*pharmacologyen
dc.subjectCattleen
dc.subjectCell Division/drug effectsen
dc.subjectCells, Cultureden
dc.subjectEndothelium, Vascular/cytology/drug effectsen
dc.subjectFibroblast Growth Factor 2/pharmacologyen
dc.subjectFlavonoids/*pharmacologyen
dc.subjectHumansen
dc.subjectMitosis/drug effectsen
dc.subjectNeovascularization, Pathologic/*prevention & controlen
dc.titleFlavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesisen
heal.abstractConsumption of a plant-based diet can prevent the development and progression of chronic diseases associated with extensive neovascularization, including solid malignant tumors. In previous studies, we have shown that the plant-derived isoflavonoid genistein is a potent inhibitor of cell proliferation and in vitro angiogenesis. In the present study, we report that certain structurally related flavonoids are more potent inhibitors than genistein. Indeed, 3-hydroxyflavone, 3',4'-dihydroxyflavone, 2',3'-dihydroxyflavone, fisetin, apigenin, and luteolin inhibited the proliferation of normal and tumor cells, as well as in vitro angiogenesis, at half-maximal concentrations in the low micromolar range. We have previously demonstrated that genistein concentrations in the urine of subjects consuming a plant-based diet is 30-fold higher than in subjects consuming a traditional Western diet. The wider distribution and the more abundant presence of flavonoids in the plant kingdom, together with the present results, suggest that flavonoids may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9230201-
heal.journalNameCancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1997-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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