Zinc(II) binding ability of tri-, tetra- and penta-peptides containing two or three histidyl residues
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Dalton Transactions
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Macroscopic and microscopic protonation processes and zinc( II) complexes of a series of multihistidine peptides ( Ac-HGH-OH, Ac-HGH-NHMe, Ac-HHGH-OH, Ac-HHGH-NHMe, Ac-HVGDH-NH2, Ac-HHVGD-NH2, Ac-HVHAH-NH2, Ac-HAHVH-NH2, Ac-HPHAH-NH2 and Ac-HAHPH-NH2) were studied by potentiometric, NMR and ESI-MS spectroscopic techniques. Protonations of histidyl imidazole-N donor functions were not much affected by the number and location of histidyl residues, but the presence of C-terminal carboxylate groups had a signi. cant impact on the basicities of the neighbouring histidyl sites. The formation of 2N(im) and 3N(im) macrochelates with the stoichiometry of [ZnL] was the major process in the complexation reactions of all peptides followed by the formation of hydroxo or amide bonded species. Thermodynamic stabilities of the zinc( II) complexes were primarily determined by the number of histidyl residues, but the presence of C-terminal carboxylate functions has also a signi. cant contribution to metal binding. The stabilizing effect of the aspartyl beta-carboxylate group was also observed, but its extent is much weaker than that of the C-terminal carboxylate with a neighbouring histidyl residue. Zinc( II) promoted peptide amide deprotonation and co-ordination was observed only in the zinc( II)-Ac-HHVGD-NH2 system above pH 8.
Περιγραφή
Λέξεις-κλειδιά
nuclear-magnetic-resonance, cysteine and/or histidine, amino-acids, copper(ii) complexes, solution behavior, metal-complexes, dipeptides, tripeptides, derivatives, stability
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000249345600009
http://pubs.rsc.org/en/content/articlepdf/2007/dt/b706303b
http://pubs.rsc.org/en/content/articlepdf/2007/dt/b706303b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας