Autoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemia

Απλή σελίδα τεκμηρίου
dc.contributor.authorTsouli, S. G.en
dc.contributor.authorKiortsis, D. N.en
dc.contributor.authorLourida, E. S.en
dc.contributor.authorXydis, V.en
dc.contributor.authorTsironis, L. D.en
dc.contributor.authorArgyropoulou, M. I.en
dc.contributor.authorElisaf, M.en
dc.contributor.authorTselepis, A. D.en
dc.date.accessioned2015-11-24T16:52:57Z
dc.date.available2015-11-24T16:52:57Z
dc.identifier.issn0022-2275-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9947
dc.rightsDefault Licence-
dc.subjectantibodyen
dc.subjectoxidized low density lipoproteinen
dc.subjectplatelet-activating factor acetylhydrolaseen
dc.subjectphospholipase a(2)en
dc.subjectlow-density-lipoproteinen
dc.subjectacute coronary syndromesen
dc.subjectactivating-factor-acetylhydrolaseen
dc.subjectoxidized ldlen
dc.subjectoxidative modificationen
dc.subjectartery-diseaseen
dc.subjectheart-diseaseen
dc.subjectatherosclerosisen
dc.subjectantibodiesen
dc.subjectxanthomasen
dc.titleAutoantibody titers against OxLDL are correlated with Achilles tendon thickness in patients with familial hypercholesterolemiaen
heal.abstractAchilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A(2) (Lp-PLA(2)) may play important roles in atherogenesis. We investigated the possible association between plasma levels of OxLDL, Lp-PLA(2) activity, and autoantibody titers against various types of mildly OxLDL with Achilles tendon thickness (ATT). ATT was determined by sonography in 80 unrelated heterozygous FH patients. Three different types of mildly OxLDL were prepared: OxLDL(L), OxLDL(P), and OxLDL(D), at the end of the lag, propagation, and decomposition phases of oxidation, respectively. Similar types of OxLDL were also prepared after inactivation of the LDL-associated Lp-PLA(2). These types were denoted OxLDL(-)(L), OxLDL(-)(P), and OxLDL(-)(D). FH patients exhibited significantly higher plasma OxLDL levels and serum IgG titers against OxLDLP and OxLDLD compared with 40 normolipidemic apparently healthy controls. ATT values were positively correlated with autoantibody titers against OxLDLP and OxLDLD; however, in multiple regression analysis, ATT was independently associated only with the autoantibody titers against OxLDLD. We conclude that the IgG autoantibody titers against OxLDLD but not OxLDL or Lp-PLA(2) may play an important role in the pathogenesis of Achilles tendon xanthomas in FH patients.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1194/jlr.M600109-JLR200-
heal.identifier.secondary<Go to ISI>://000240847600011-
heal.identifier.secondaryhttp://www.jlr.org/content/47/10/2208.full.pdf-
heal.journalNameJournal of Lipid Researchen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2006-
heal.publisherAmerican Society for Biochemistry and Molecular Biology, Inc.en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ