Changes in the hepatic copper conent after treatment with foreign compounds
| dc.contributor.author | Torronen, R. | en |
| dc.contributor.author | Marselos, M. | en |
| dc.date.accessioned | 2015-11-24T19:31:01Z | |
| dc.date.available | 2015-11-24T19:31:01Z | |
| dc.identifier.issn | 0171-9750 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23193 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Chelating Agents/pharmacology | en |
| dc.subject | Copper/*metabolism | en |
| dc.subject | Disulfiram/pharmacology | en |
| dc.subject | Liver/drug effects/*metabolism | en |
| dc.subject | Male | en |
| dc.subject | Phenobarbital/pharmacology | en |
| dc.subject | Pyrazoles/pharmacology | en |
| dc.subject | Rats | en |
| dc.title | Changes in the hepatic copper conent after treatment with foreign compounds | en |
| heal.abstract | The effects of dimercaprol, CaNa2EDTA, D-penicillamine, diethyldithiocarbamate, disulfiram, pyrazole and phenobarbital on the hepatic copper content were studied. Adult male albino rats were given these compounds subcutaneously or intragastrically for 4 or 7 days, and the copper content in the hepatic crude homogenate was measured with an atomic absorption spectrophotometer. The metal chelating compounds dimercaprol, D-penicillamine and diethyldithiocarbamate only slightly decreased the level of copper in the liver. CaNa2 EDTA caused no change in the copper content. A slight decrease was found also after phenobarbital treatment. On the contrary, disulfiram and pyrazole increased the copper content 3- and 2-fold, respectively. It is suggested that the accumulation of copper in the liver is due to the cholestatic action of disulfiram and pyrazole. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/277109 | - |
| heal.journalName | Arch Toxicol Suppl | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1978 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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