Acute limb ischemia caused by femoral arterial line induces remote liver injury in a rabbit model of liver ischemia/reperfusion injury

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dc.contributor.authorGlantzounis, G. K.en
dc.contributor.authorSheth, H.en
dc.contributor.authorThompson, C.en
dc.contributor.authorHafez, T. S.en
dc.contributor.authorKanoria, S.en
dc.contributor.authorPamecha, V.en
dc.contributor.authorDavies, S.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorSeifalian, A. M.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T19:38:02Z
dc.date.available2015-11-24T19:38:02Z
dc.identifier.issn1940-1574-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24102
dc.rightsDefault Licence-
dc.subjectAlanine Transaminase/blooden
dc.subjectAnimalsen
dc.subjectBile/metabolismen
dc.subjectBiological Markers/blooden
dc.subjectBlood Pressureen
dc.subjectCatheterization, Peripheral/*adverse effectsen
dc.subjectDisease Models, Animalen
dc.subjectEar/*blood supplyen
dc.subjectExtremities/*blood supplyen
dc.subject*Femoral Arteryen
dc.subjectHeart Rateen
dc.subjectIschemia/complications/*etiology/physiopathologyen
dc.subjectLactic Acid/blooden
dc.subjectLiver/*blood supply/metabolism/pathologyen
dc.subjectLiver Diseases/*etiology/metabolism/pathology/physiopathologyen
dc.subjectLiver Function Testsen
dc.subjectNecrosisen
dc.subjectNeutrophil Infiltrationen
dc.subjectRabbitsen
dc.subjectReperfusion Injury/*etiology/metabolism/pathologyen
dc.subjectTime Factorsen
dc.titleAcute limb ischemia caused by femoral arterial line induces remote liver injury in a rabbit model of liver ischemia/reperfusion injuryen
heal.abstractFemoral arterial lines are used for continuous monitoring of arterial blood pressure in experimental studies. However, placement of a catheter in the femoral artery could produce acute limb ischemia with associated systemic effects. The aim of this study was to investigate the effect of femoral arterial line insertion on liver function, in a rabbit liver lobar ischemia-reperfusion (I/R) model. Four groups of animals (n = 6 each) were studied: groups 1 and 2 (sham) underwent laparotomy but no liver ischemia. In groups 3 and 4 (I/R), liver lobar ischemia was induced for 60 minutes followed by 7 hours of reperfusion. In groups 1 and 3, the arterial line was placed in the femoral artery whereas in groups 2 and 4 in the ear artery. Liver function was assessed by serum alanine aminotransferase (ALT) activity, bile flow, plasma lactate levels, and histology. Results are expressed as mean +/- SEM. Alanine aminotransferase activity and lactate levels were significantly higher in the I/R femoral line group compared with the I/R ear line group at 7 hours postreperfusion. Bile production was significantly lower (75 +/- 9.6 vs 112 +/- 10 microL/min per 100 g liver weight). Histopathology showed more extensive hepatocellular necrosis and neutrophil accumulation in the I/R femoral line group compared with I/R ear line group. The sham femoral group showed liver injury, which was more marked than the ear line group (all P < .05). In conclusion, femoral artery cannulation induces remote liver injury. The use of femoral arterial lines should be avoided in experimental studies concerning liver function.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1177/0003319709338176-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19625265-
heal.identifier.secondaryhttp://ang.sagepub.com/content/60/5/554.full.pdf-
heal.journalNameAngiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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