Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices

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dc.contributor.authorIoachim, E.en
dc.contributor.authorKitsiou, E.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorMitselou, A.en
dc.contributor.authorZagorianakou, N.en
dc.contributor.authorMakrydimas, G.en
dc.contributor.authorTzioras, S.en
dc.contributor.authorSalmas, M.en
dc.date.accessioned2015-11-24T19:12:00Z
dc.date.available2015-11-24T19:12:00Z
dc.identifier.issn1048-891X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20997
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectCarcinoma, Endometrioid/*immunology/pathologyen
dc.subjectCathepsin D/biosynthesis/*immunologyen
dc.subjectCell Transformation, Neoplastic/*immunologyen
dc.subjectEndometrial Hyperplasia/*immunology/pathologyen
dc.subjectEndometrial Neoplasms/*immunology/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Proteins/immunologyen
dc.subjectNeoplasm Stagingen
dc.subjectNuclear Proteins/immunologyen
dc.subjectPrecancerous Conditions/*immunology/pathologyen
dc.subjectPrognosisen
dc.subjectReceptors, Steroid/immunologyen
dc.titleImmunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indicesen
heal.abstractThe immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers. The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12801267-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/doi/10.1046/j.1525-1438.2003.13181.x/abstract-
heal.journalNameInt J Gynecol Canceren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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