Axonal regeneration stimulated by erythropoietin: an experimental study in rats

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dc.contributor.authorLykissas, M. G.en
dc.contributor.authorSakellariou, E.en
dc.contributor.authorVekris, M. D.en
dc.contributor.authorKontogeorgakos, V. A.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorMitsionis, G. I.en
dc.contributor.authorBeris, A. E.en
dc.date.accessioned2015-11-24T19:33:42Z
dc.date.available2015-11-24T19:33:42Z
dc.identifier.issn0165-0270-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23561
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectDenervation/adverse effectsen
dc.subjectErythropoietin/*pharmacology/therapeutic useen
dc.subjectGanglia, Spinal/drug effects/metabolism/physiopathologyen
dc.subjectGrowth Cones/*drug effects/physiologyen
dc.subjectMaleen
dc.subjectMotor Neurons/drug effects/metabolismen
dc.subjectMuscle, Skeletal/innervation/pathology/physiopathologyen
dc.subjectNerve Growth Factors/*pharmacology/therapeutic useen
dc.subjectNerve Regeneration/*drug effects/physiologyen
dc.subjectNeurons, Afferent/drug effects/metabolismen
dc.subjectNeurosurgical Procedures/methodsen
dc.subjectOrgan Sizeen
dc.subjectPeripheral Nerve Injuriesen
dc.subjectPeripheral Nerves/*drug effects/surgeryen
dc.subjectPeroneal Nerve/drug effects/injuries/surgeryen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectRecovery of Function/drug effects/physiologyen
dc.subjectTibial Nerve/drug effects/injuries/surgeryen
dc.subjectTreatment Outcomeen
dc.subjectWithholding Treatmenten
dc.titleAxonal regeneration stimulated by erythropoietin: an experimental study in ratsen
heal.abstractThe aim of the present study is to evaluate the effects of erythropoietin to the collateral sprouting by using systemically delivered erythropoietin in an end-to-side nerve repair model. Forty-five rats were evaluated in four groups: (A) end-to-side neurorrhaphy only, (B) end-to-side neurorrhaphy and erythropoietin administration, (C) end-to-end neurorrhaphy and (D) nerve stumps buried into neighboring muscles. In all animals, the contralateral healthy side served as control. Functional assessment of nerve regeneration was performed at intervals up to 5 months using the Peroneal Function Index. Evaluation 150 days after surgery included peroneal and tibial nerve morphometric examination, and wet weights of the tibialis anterior muscle. During the first three weeks after surgery, when erythropoietin was regularly administered, functional evaluation showed that erythropoietin may facilitate peripheral nerve regeneration. However, there was rapid deterioration in the functional recovery when erythropoietin's administration was discontinued. As a consequence, at the end of this study, erythropoietin failed to maintain its initial stimulating effect in axonal regeneration. The results of wet muscle weights revealed statistically significant differences between Groups A and C, and Group B. Furthermore, data on axonal counting showed significant difference between Groups A and C, and Group B. Erythropoietin appears to facilitate peripheral nerve regeneration at the initial phase of its administration. Further investigation will be necessary to optimise the conditions (dose, mode of administration) in order to maintain its effects.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.jneumeth.2007.04.008-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17532473-
heal.identifier.secondaryhttp://ac.els-cdn.com/S016502700700180X/1-s2.0-S016502700700180X-main.pdf?_tid=4dd1b6e3886bf08080caedb538098083&acdnat=1333348479_9699b86c9f48ef01671bb4ef5186fcf8-
heal.journalNameJ Neurosci Methodsen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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