The changes in plasma retinol-binding protein 4 levels are associated with those of the apolipoprotein B-containing lipoproteins during dietary and drug treatment
| dc.contributor.author | Christou, G. A. | en |
| dc.contributor.author | Tellis, C. C. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Kiortsis, D. N. | en |
| dc.date.accessioned | 2015-11-24T19:42:19Z | |
| dc.date.available | 2015-11-24T19:42:19Z | |
| dc.identifier.issn | 1940-1574 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24623 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Apolipoproteins B/*blood | en |
| dc.subject | Caloric Restriction | en |
| dc.subject | Diet, Fat-Restricted | en |
| dc.subject | Female | en |
| dc.subject | Fenofibrate/therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Hypertriglyceridemia/*blood/etiology/*therapy | en |
| dc.subject | Hypolipidemic Agents/therapeutic use | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Obesity/*blood/complications/*therapy | en |
| dc.subject | Piperidines/therapeutic use | en |
| dc.subject | Pyrazoles/therapeutic use | en |
| dc.subject | Retinol-Binding Proteins, Plasma/*metabolism | en |
| dc.title | The changes in plasma retinol-binding protein 4 levels are associated with those of the apolipoprotein B-containing lipoproteins during dietary and drug treatment | en |
| heal.abstract | We investigated the association between retinol-binding protein 4 (RBP(4)) and apolipoprotein B (ApoB)-containing lipoproteins. Obese or overweight, hypertriglyceridemic patients underwent the following interventions for 3 months: (1) Diet (n = 20), (2) Diet + fenofibrate (n = 18), (3) Diet + rimonabant (n = 8). Circulating RBP4 decreased during dietary treatment. The percentage change in RBP(4) was positively correlated with the percentage changes in very-low density lipoprotein cholesterol (r = .570, P = .02), low-density lipoprotein cholesterol ([LDL-C]; r = .605, P = .01), ApoB (r = .705, P = .007), and small dense LDL-C ([sdLDL-C]; r = .872, P < .001). The percentage change in RBP4 was the best predictor of the percentage changes in sdLDL-C and ApoB. Rimonabant treatment reduced RBP4, whereas fenofibrate increased RBP4 during the first month of therapy followed by a subsequent decrease. In conclusion, RBP4 may significantly influence the metabolic pathways responsible for changes in ApoB lipoprotein subspecies, thus RBP4 may be associated with cardiovascular disease risk. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1177/0003319711407628 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21602259 | - |
| heal.identifier.secondary | http://ang.sagepub.com/content/63/1/67.full.pdf | - |
| heal.journalName | Angiology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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