Effect of letrozole on the lipid profile in postmenopausal women with breast cancer
Φόρτωση...
Ημερομηνία
Συγγραφείς
Elisaf, M. S.
Bairaktari, E. T.
Nicolaides, C.
Kakaidi, B.
Tzallas, C. S.
Katsaraki, A.
Pavlidis, N. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase inhibitor that effectively blocks aromatase activity without interfering with adrenal steroid biosynthesis. The drug can significantly reduce the levels of plasma oestrogens, which remain suppressed throughout the treatment. Data are scarce concerning the influence of these drugs on serum lipid levels. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile.
Περιγραφή
Λέξεις-κλειδιά
Aged, Antineoplastic Agents/*adverse effects, Apolipoprotein A-I/blood, Apolipoproteins B/blood, Apolipoproteins E/blood, Breast Neoplasms/blood/*drug therapy, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Enzyme Inhibitors/*adverse effects, Female, Humans, Lipids/*blood, Lipoprotein(a)/blood, Middle Aged, Nitriles/*adverse effects, Postmenopause/*blood, Risk Factors, Triazoles/*adverse effects, Triglycerides/blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11506958
http://ac.els-cdn.com/S0959804901001551/1-s2.0-S0959804901001551-main.pdf?_tid=af73e4e734f63bc0886fbb8f9586b3e9&acdnat=1333611149_9efc2a6d09ced7930dec9ff3ecf02937
http://ac.els-cdn.com/S0959804901001551/1-s2.0-S0959804901001551-main.pdf?_tid=af73e4e734f63bc0886fbb8f9586b3e9&acdnat=1333611149_9efc2a6d09ced7930dec9ff3ecf02937
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής