Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C
| dc.contributor.author | Kallistratos, G. | en |
| dc.contributor.author | Fasske, E. | en |
| dc.date.accessioned | 2015-11-24T19:09:51Z | |
| dc.date.available | 2015-11-24T19:09:51Z | |
| dc.identifier.issn | 0171-5216 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20758 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Ascorbic Acid/*pharmacology | en |
| dc.subject | Benzopyrenes/*toxicity | en |
| dc.subject | Dose-Response Relationship, Drug | en |
| dc.subject | Fibrosarcoma/chemically induced | en |
| dc.subject | Neoplasms, Experimental/*chemically induced/prevention & control | en |
| dc.subject | Rats | en |
| dc.subject | Rhabdomyosarcoma/chemically induced | en |
| dc.subject | Sarcoma, Experimental/chemically induced | en |
| dc.title | Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C | en |
| heal.abstract | The s.c. infection of 10 mg benzo(a)pyrene dissolved in 1 ml tricaprylin induced in Wistar rats local malignant tumors, such as fibrosarcoma, rhabdomyosarcoma, and polymorph cell sarcoma. The growth of the tumors was relatively rapid, reaching weights of 140-155 g before rats died 142-168 days after the administration of the carcinogen. On the contrary, under the same experimental conditions, high doses of Vitamin C about 525 mg/day/rat administered orally in drinking water (total amount of Vitamin C 55 g/rat corresponding to 40% of their body weight ) inhibited to a great extent the benzo(a)pyrene carcinogenesis. Only one slowly growing rhabdomyosarcoma (13 g of weight) was developed showing characteristic damage of malignant cells and partial replacement of the neoplastic area with granuloma tissue. The significance ov Vitamin C for cancer prevention and treatment is discussed. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7400211 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/l2401241jp943026/fulltext.pdf | - |
| heal.journalName | J Cancer Res Clin Oncol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1980 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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