CNS involvement in primary Sjogren Syndrome: assessment of gray and white matter changes with MRI and voxel-based morphometry

Απλή σελίδα τεκμηρίου
dc.contributor.authorTzarouchi, L. C.en
dc.contributor.authorTsifetaki, N.en
dc.contributor.authorKonitsiotis, S.en
dc.contributor.authorZikou, A.en
dc.contributor.authorAstrakas, L.en
dc.contributor.authorDrosos, A.en
dc.contributor.authorArgyropoulou, M. I.en
dc.date.accessioned2015-11-24T19:30:09Z
dc.date.available2015-11-24T19:30:09Z
dc.identifier.issn1546-3141-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23029
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBrain Diseases/*pathologyen
dc.subjectBrain Mappingen
dc.subjectCase-Control Studiesen
dc.subjectChi-Square Distributionen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisteden
dc.subjectLinear Modelsen
dc.subjectMagnetic Resonance Imaging/*methodsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNerve Fibers/*pathologyen
dc.subjectSjogren's Syndrome/*pathologyen
dc.subjectStatistics, Nonparametricen
dc.titleCNS involvement in primary Sjogren Syndrome: assessment of gray and white matter changes with MRI and voxel-based morphometryen
heal.abstractOBJECTIVE: The purpose of this study was to evaluate with MRI the involvement of gray matter and white matter structures in patients with primary Sjogren syndrome. SUBJECTS AND METHODS: Fifty-three patients with primary Sjogren syndrome, 18 age- and disease duration-matched patients with systemic sclerosis, and 35 age-matched control subjects were examined for differences in white matter hyperintensities (WMHIs) detected on FLAIR MR images. Differences in brain volume between patients with primary Sjogren syndrome and controls were studied by application of voxel-based morphometry to a 3D T1-weighted sequence. RESULTS: WMHIs were observed in 38 of the 53 patients with primary Sjogren syndrome, six of 18 patients with systemic sclerosis, and 17 of 35 controls. The numbers of WMHIs 2 mm or larger and the number smaller than 2 mm were higher in patients with primary Sjogren syndrome than in controls (>/= 2 mm, p = 0.004; < 2 mm, p < 0.001). No significant difference was observed in the number of WMHIs in primary Sjogren syndrome patients and that in systemic sclerosis patients. After control for age, a positive relation was found between disease duration and total number of WMHIs (p = 0.037) and number of WMHIs 2 mm or larger (p = 0.023) in patients with primary Sjogren syndrome. In comparison with the controls, patients with primary Sjogren syndrome had decreased gray matter volume in the cortex, deep gray matter, and cerebellum. Associated loss of white matter volume was observed in areas corresponding to gray matter atrophy and in the corpus callosum (p < 0.05). CONCLUSION: Patients with primary Sjogren syndrome have WMHIs and gray and white matter atrophy, probably related to cerebral vasculitis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.2214/AJR.10.5984-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22021516-
heal.identifier.secondaryhttp://www.ajronline.org/content/197/5/1207-
heal.journalNameAJR Am J Roentgenolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ