Synthesis, study and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activity
| dc.contributor.author | Zachariadis, P. C. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Michaelides, A. | en |
| dc.contributor.author | Skoulika, S. | en |
| dc.contributor.author | Ming, Y. | en |
| dc.contributor.author | Yu, X. L. | en |
| dc.date.accessioned | 2015-11-24T16:49:52Z | |
| dc.date.available | 2015-11-24T16:49:52Z | |
| dc.identifier.issn | 0020-1693 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9539 | |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | silver(i) complexes | en |
| dc.subject | 2-mercapto-nicotinic acid | en |
| dc.subject | crystal structures | en |
| dc.subject | anti-hiv-rt activity | en |
| dc.subject | complexes | en |
| dc.subject | crystal | en |
| dc.subject | ligands | en |
| dc.title | Synthesis, study and structural characterization of a new water soluble hexanuclear silver(I) cluster with the 2-mercapto-nicotinic acid with possible antiviral activity | en |
| heal.abstract | Silver(I) chloride reacts with 2-mercapto-nicotinic acid (H(2)mna, C6H5NO2S) in the presence of an excess of triethylamine in DMSO to form a hexanuclear, water soluble, cluster of formula {[Ag-6(mu(3)-Hmna)(4)(mu(3)-mna)(2)](2-) (.)[(Et3NH)(+)](2)(.)(DMSO)(2)(.)(H2O)} (1). The complex 1 was characterized by elemental analyses, and FT-IR, UV-Vis and H-1 NMR spectroscopy. Crystal structures of complex 1 and the ligand, 2-mecapto-nicotinic acid (2), have been determined by X-ray diffraction. Compound 1, C52H68Ag6-N8O15S8, is monoclinic with a space group P2(1)/c (No. 14) and a = 11.7080(10), b = 16.2920(10), c = 18.3010(10) Angstrom, beta = 91.350(10)degrees, Z = 4. The entire molecule is ionic and consists of a double anionic hexa-nuclear cluster and two protonated triethylamine counter cations while it is solvated by two DMSO and one water molecule. The 2-mercapto-nicotinic acid (2), C6H5NO2S, is orthorhombic (space group Pna2(1) (No. 33), a = 8.3910(10), b = 13.2720(10), c = 5.892 Angstrom, Z = 4). An extended inter-molecular hydrogen bonding via (OH)-H-...-N contacts (O(1)H-...(5)[N(5)] = 1.8998, O(1)N-...(5) = 2.8049 Angstrom) links the molecules forming a supramolecular two-dimensional network. Complex 1, was evaluated for anti-HIV-RT activity. It was found to inhibit the human immunodeficiency viral replication reverse transcriptase (HIV-RT) with calculated inhibiting concentration (IC50) 0.01275 +/- 0.00115 mg ml(-1). (C) 2002 Elsevier Science B.V. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/S0020-1693(02)01210-0 | - |
| heal.identifier.secondary | <Go to ISI>://000180870200044 | - |
| heal.journalName | Inorganica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: