Influence of propofol and volatile anaesthetics on the inflammatory response in the ventilated lung

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dc.contributor.authorKalimeris, K.en
dc.contributor.authorChristodoulaki, K.en
dc.contributor.authorKarakitsos, P.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorLekka, M.en
dc.contributor.authorBai, M.en
dc.contributor.authorKitsiouli, E.en
dc.contributor.authorNakos, G.en
dc.contributor.authorKostopanagiotou, G.en
dc.date.accessioned2015-11-24T16:39:52Z
dc.date.available2015-11-24T16:39:52Z
dc.identifier.issn0001-5172-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8201
dc.rightsDefault Licence-
dc.subjectactivating-factor acetylhydrolaseen
dc.subjectoxidative stress statusen
dc.subjectmechanical ventilationen
dc.subjectalveolar macrophagesen
dc.subjectsevoflurane anesthesiaen
dc.subjectepithelial-cellsen
dc.subjectoleic-aciden
dc.subjectii cellsen
dc.subjectinjuryen
dc.subjecthalothaneen
dc.titleInfluence of propofol and volatile anaesthetics on the inflammatory response in the ventilated lungen
heal.abstractBackground: The immunomodulatory effects of volatile anaesthetics in vitro and the protective effect of propofol in lung injury spurred us to study the effects of volatile anaesthetics and propofol on lung tissue in vivo. Methods: Twenty-seven pigs were randomized to 4-h general anaesthesia with propofol (8 mg/kg/h, group P, n=9), sevoflurane [minimum alveolar concentration (MAC)=1.0, group S, n=9) or desflurane (MAC=1.0, group D, n=9). Four healthy animals served as the no-ventilation group. Bronchoalveolar lavage fluid (BALF) was obtained to measure the cell counts, platelet-activating factor acetylhydrolase (PAF-AcH), phospholipase A(2) (PLA(2)) and superoxide dismutase (SOD) activity. Lung tissues were evaluated histologically and for caspase-3 expression. Results: Volatile anaesthetics reduced PAF-AcH levels without affecting PLA(2) activity and resulted in decreased alveolar macrophage and increased lymphocyte counts in BALF (sevoflurane: 29 +/- 23%; desflurane: 26 +/- 6%, both P<0.05 compared with 4 +/- 2% in the no-ventilation group). These findings were accompanied by atelectasis and inflammatory cells' infiltration in the inhalational anaesthetics groups. Also, sevoflurane reduced SOD activity and both sevoflurane and desflurane induced significant caspase-3 expression. In contrast, propofol resulted in a minor degree of inflammation and preserved BALF cells' composition without triggering apoptosis. Conclusion: Halogenated anaesthetics seem to trigger an immune lymphocytic response in the lung, inducing significant apoptosis and impairment of PAF-AcH. In contrast, propofol preserves anti-inflammatory and antioxidant defences during mechanical ventilation, thus preventing the emergence of apoptosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1111/j.1399-6576.2011.02461.x-
heal.identifier.secondary<Go to ISI>://000292100800017-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1399-6576.2011.02461.x/asset/j.1399-6576.2011.02461.x.pdf?v=1&t=h0dxryax&s=b21f1f152dec0fdcd05dd0f433466478bc42ba08-
heal.journalNameActa Anaesthesiol Scanden
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.publisherWiley-Blackwellen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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