Urticaria and angiedema-like skin reactions in a patient treated with adalimumab
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Date
Authors
Nikas, S. N.
Voulgari, P. V.
Drosos, A. A.
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peer-reviewed
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Clin Rheumatol
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Description
Specific inhibition of the cytokine tumor necrosis factor alpha has resulted in significant clinical and laboratory improvement of patients with chronic inflammatory diseases of Th1 phenotype. Etanercept is a recombinant fusion protein of two p75 soluble receptors, while infliximab is a chimeric monoclonal antibody. Both have been considered to be immunogenic and cause various immune-mediated skin reactions. On the other hand, adalimumab, a human monoclonal antibody, was expected to cause little or no immune-mediated skin reactions. Herein, we report a patient with rheumatoid arthritis treated with adalimumab, who after the seventh injection, developed angiedema affecting the lips and face, as well as an urticaria-like skin reaction affecting the trunk. These reactions were followed by hypotension. The patient was treated appropriately and after 2 h, the rashes and the edema disappeared and the patient gradually recovered completely. Adalimumab was discontinued.
Description
Keywords
Antibodies, Monoclonal/*adverse effects, Antibodies, Monoclonal, Humanized, Antirheumatic Agents/*adverse effects, Arthritis, Rheumatoid/*drug therapy, Female, Humans, Middle Aged, Urticaria/*chemically induced
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http://www.ncbi.nlm.nih.gov/pubmed/16421645
http://www.springerlink.com/content/p4kx2254886309xv/fulltext.pdf
http://www.springerlink.com/content/p4kx2254886309xv/fulltext.pdf
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής