Factors related to the presence of autoantibodies in patients with chronic mental disorders
Φόρτωση...
Ημερομηνία
Συγγραφείς
Yannitsi, S. G.
Manoussakis, M. N.
Mavridis, A. K.
Tzioufas, A. G.
Loukas, S. B.
Plataris, G. K.
Liakos, A. D.
Moutsopoulos, H. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Biol Psychiatry
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Serum samples from 307 patients with various chronic mental disorders were examined for the presence of several autoantibodies. Autoantibodies detected included antinuclear antibodies (ANA) in 122/307 (39.7%), rheumatoid factor (RF) in 23/307 (7.5%), anticardiolipin antibodies (anti-CL) in 23/304 (7.6%, IgM in 12 patients, IgG in 13 patients). Isolated cases with IgG anti-dsDNA, anti-Ro(SSA), and anti-Ro(SSA)/anti-La(SSB) were also identified. The analysis of data revealed that the aging process in patients studied contributed significantly to the incidence of ANA (p less than 0.0001) and RF (p less than 0.01). In addition, the chronic administration of chlorpromazine (CPZ) was associated with the presence of ANA (p less than 0.03) as well as with the presence of IgM and/or IgG anti-CL antibodies (p less than 0.003). Finally, the diagnosis of schizophrenia correlated with the presence of ANA (p less than 0.001). This study represents the autoantibody profile of patients with chronic mental disorders and emphasizes the multifactorial origin of autoantibody response in psychiatric patients.
Περιγραφή
Λέξεις-κλειδιά
Adult, Affective Disorders, Psychotic/immunology, Aged, Aged, 80 and over, Alcoholism/immunology, Antibodies, Antinuclear/analysis, Autoantibodies/*analysis, Borderline Personality Disorder/immunology, Chronic Disease, DNA/immunology, Delirium, Dementia, Amnestic, Cognitive Disorders/immunology, Female, Humans, Intellectual Disability/immunology, Male, Mental Disorders/*immunology, Middle Aged, Psychotic Disorders/psychology, Schizophrenia/immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/2328270
http://ac.els-cdn.com/000632239090590X/1-s2.0-000632239090590X-main.pdf?_tid=30df17e031de19a87fd7e38e57df2f75&acdnat=1337244488_36e3389629f6b79b39bb3883b6ad343a
http://ac.els-cdn.com/000632239090590X/1-s2.0-000632239090590X-main.pdf?_tid=30df17e031de19a87fd7e38e57df2f75&acdnat=1337244488_36e3389629f6b79b39bb3883b6ad343a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής