Takayasu arteritis: epidemiological, clinical, and immunogenetic features in Greece

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dc.contributor.authorKarageorgaki, Z. T.en
dc.contributor.authorBertsias, G. K.en
dc.contributor.authorMavragani, C. P.en
dc.contributor.authorKritikos, H. D.en
dc.contributor.authorSpyropoulou-Vlachou, M.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorBoumpas, D. T.en
dc.contributor.authorMoutsopoulos, H. M.en
dc.date.accessioned2015-11-24T19:43:08Z
dc.date.available2015-11-24T19:43:08Z
dc.identifier.issn0392-856X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24726
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAge of Onseten
dc.subjectAngiographyen
dc.subjectBlood Vessels/pathologyen
dc.subjectComorbidityen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectGenes, MHC Class I/*immunologyen
dc.subjectGlucocorticoids/therapeutic useen
dc.subjectGreece/epidemiologyen
dc.subjectHLA-B Antigens/genetics/immunologyen
dc.subjectHumansen
dc.subject*Immunogenetic Phenomenaen
dc.subjectImmunosuppressive Agents/therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRemission Inductionen
dc.subjectRetrospective Studiesen
dc.subject*Seroepidemiologic Studiesen
dc.subject*Takayasu Arteritis/epidemiology/genetics/immunology/therapyen
dc.subjectYoung Adulten
dc.titleTakayasu arteritis: epidemiological, clinical, and immunogenetic features in Greeceen
heal.abstractOBJECTIVE: Takayasu arteritis (TA) is an uncommon disease with clinical heterogeneity across different ethnic groups. We aimed to evaluate the epidemiological, clinical, and immuno-genetic features of TA in Greece. METHODS: Demographic, clinical, laboratory, angiographic, and therapeutic data of 42 patients from 4 large referral centers were retrieved. Serology and Human Lymphocyte Antigen (HLA) typing was performed in 22 patients. RESULTS: We studied 37 women and 5 men with a median age of 31 years at disease onset. Median delay in diagnosis was 24 months and median follow-up was 47 months (range 0-178). Constitutional or musculoskeletal symptoms were present in 86%, especially early in the disease course. Vascular findings were universal with reduced or absent pulse being the most common manifestation (98%). Hypertension was frequent (78%). Extensive disease prevailed and stenotic lesions were more common than aneurysms (95% vs. 40%). Erythrocyte sedimentation rate and C-reactive protein showed modest correlation with disease activity. HLA-B52 was expressed by 37% of the patients vs. 2.4% of the controls (p<0.001). Glucocorticoids and cytotoxic agents were used in most patients with remission rates of 83%. A total of 42 surgical procedures were performed with success rates of 87%. CONCLUSION: TA in Greece clinically and epidemiologically resembles the pattern of disease in Japan and the Western hemisphere. There is considerable delay in diagnosis, which may partially reflect failure to recognize a rare disease. New surrogate markers are needed to assess disease activity. Glucocorticoids are the cornerstone of treatment and cytotoxic drugs are frequently used as steroid sparing agents.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19646344-
heal.journalNameClin Exp Rheumatolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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