Cerebrovascular reactivity and cerebral autoregulation in normal subjects
Φόρτωση...
Ημερομηνία
Συγγραφείς
Carrera, E.
Lee, L. K.
Giannopoulos, S.
Marshall, R. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Neurol Sci
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Cerebrovascular reactivity (CVR) testing with CO2 challenge is used clinically as a measure of cerebrovascular reserve. However it is not known whether CVR measures the same physiological process as spontaneous cerebral autoregulation (CA). PURPOSE: To compare CVR with CA in healthy volunteers, using continuous monitoring of cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP). METHODS: We prospectively studied CVR and CA in 18 healthy volunteers. CVR was assessed using mean CBFV changes after 5% CO2 inhalation. CA was determined by transfer function analysis to derive the phase shift between spontaneous ABP and CBFV fluctuations at 0.1 Hz. RESULTS: CO2 inhalation produced a significant decrease in phase shift from 37.9+/-13.8 degrees to 21.0+/-7.2 degrees (p<0.001). In addition, there was a significant correlation between CVR and CA changes during CO2 inhalation (R=-0.50, p=0.03), but not between CVR and baseline CA (R=0.22, p=0.4). CONCLUSION: We showed a decrease in spontaneous CA after vasodilatation. However, the lack of correlation between baseline CA and degree of CVR suggests that cerebrovascular reserve and CA are based in part on distinct physiological mechanisms. Further studies are needed to determine which of these parameters is most useful to guide treatment decisions in pathological states.
Περιγραφή
Λέξεις-κλειδιά
Adult, Blood Flow Velocity, Blood Pressure, Blood Pressure Determination, Brain/*blood supply/*physiology, Carbon Dioxide/metabolism, Cerebrovascular Circulation/*physiology, Female, Homeostasis/*physiology, Humans, Male, Monitoring, Physiologic, Prospective Studies, Vasodilation/physiology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/19608202
http://ac.els-cdn.com/S0022510X09006984/1-s2.0-S0022510X09006984-main.pdf?_tid=c9b2380381c051fb5dcf43ad9630b51f&acdnat=1332830789_4ba654e54b13e8eaf65a7145706047d9
http://ac.els-cdn.com/S0022510X09006984/1-s2.0-S0022510X09006984-main.pdf?_tid=c9b2380381c051fb5dcf43ad9630b51f&acdnat=1332830789_4ba654e54b13e8eaf65a7145706047d9
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής