DNA strand breakage induced by Cu(II) and Ni(II), in the presence of peptide models of histone H2B
| dc.contributor.author | Zavitsanos, K. | en |
| dc.contributor.author | Nunes, A. M. | en |
| dc.contributor.author | Malandrinos, G. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.date.accessioned | 2015-11-24T16:56:30Z | |
| dc.date.available | 2015-11-24T16:56:30Z | |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10447 | |
| dc.rights | Default Licence | - |
| dc.subject | histone h2b | en |
| dc.subject | copper(ii) | en |
| dc.subject | nickel(ii) | en |
| dc.subject | toxicity | en |
| dc.subject | strand breakage | en |
| dc.subject | methionine sulfoxide reductase | en |
| dc.subject | nucleosome core particle | en |
| dc.subject | intrastrand cross-links | en |
| dc.subject | oxidative DNA | en |
| dc.subject | mammalian chromatin | en |
| dc.subject | hydrogen-peroxide | en |
| dc.subject | nickel carcinogenesis | en |
| dc.subject | antioxidant defense | en |
| dc.subject | angstrom resolution | en |
| dc.subject | terminal sequence | en |
| dc.title | DNA strand breakage induced by Cu(II) and Ni(II), in the presence of peptide models of histone H2B | en |
| heal.abstract | In the present study we used the plasmid relaxation assay, a very sensitive method for detection of DNA strand breaks in vitro, in order to evaluate the role of peptide fragments of histone H2B in DNA strand breakage induced by copper and nickel. We have found that in the presence of peptides modeling the histone fold domain (H2B(32-62) and H2B(63-93)) as well as the N-terminal tail (H2B(1-31)) of histone H2B there is an increased DNA damage by Cu(2+)/H(2)O(2) and Ni(2+)/H(2)O(2) reaction mixtures. On the contrary, the C-terminal tail (H2B(94-125)) seems to have a protective role on the attack of ROS species to DNA. We have rendered our findings to the interactions of the peptides with DNA, as well as with the metal. (C) 2011 Elsevier Inc. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1016/j.jinorgbio.2011.07.014 | - |
| heal.identifier.secondary | <Go to ISI>://000295423700009 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013411001942/1-s2.0-S0162013411001942-main.pdf?_tid=50b5bcf3491cc88c2d03a55cd7fcfb89&acdnat=1333034677_65c28d526a549fe767a335033b73de1a | - |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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