Topography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive rats

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dc.contributor.authorKonitsiotis, S.en
dc.contributor.authorKafetzopoulos, E.en
dc.date.accessioned2015-11-24T19:14:16Z
dc.date.available2015-11-24T19:14:16Z
dc.identifier.issn0014-2999-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21277
dc.rightsDefault Licence-
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectApomorphine/pharmacologyen
dc.subjectBehavior, Animal/*drug effectsen
dc.subjectBenzazepines/*pharmacologyen
dc.subjectCorpus Striatum/*drug effectsen
dc.subjectDopamine Antagonistsen
dc.subjectInjections, Intraperitonealen
dc.subjectInjections, Intraventricularen
dc.subjectMaleen
dc.subjectMotor Activity/*drug effectsen
dc.subjectRatsen
dc.subjectRats, Inbred Strainsen
dc.subjectReceptors, Dopamine/*drug effectsen
dc.subjectReceptors, Dopamine D1en
dc.subjectReceptors, Dopamine D2en
dc.subjectSulpiride/*pharmacologyen
dc.titleTopography of dopamine D-1 and D-2 receptor-mediated rotation after intrastriatal injections of dopamine-related drugs in normosensitive ratsen
heal.abstractNaive rats were challenged systematically with apomorphine after receiving unilateral dorsal or ventral intracaudate injections of the dopamine D-1 receptor antagonist, SCH23390, or the D-2 receptor antagonist, sulpiride. Sulpiride injections into both the dorsal and ventral striatum induced a robust ipsilateral rotation, while SCH23390 elicited a weaker ipsilateral rotation only on injection into the ventral striatum. Both drugs were ineffective in saline-treated rats, although sulpiride injections into the ventral striatum after systemic saline elicited a small ipsilateral preference. The results from this rotational model mediated by normosensitive receptors indicate that only dopamine D-1 receptors in the ventral striatum mediate rotation while D-2 receptors in both striatal regions mediate rotation. A functional dichotomy between these two neostriatal regions is thus proposed.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/2142084-
heal.journalNameEur J Pharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1990-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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