Cholecystokinin and gallbladder contraction: effect of CCK infusion
| dc.contributor.author | Byrnes, D. J. | en |
| dc.contributor.author | Borody, T. | en |
| dc.contributor.author | Daskalopoulos, G. | en |
| dc.contributor.author | Boyle, M. | en |
| dc.contributor.author | Benn, I. | en |
| dc.date.accessioned | 2015-11-24T19:30:41Z | |
| dc.date.available | 2015-11-24T19:30:41Z | |
| dc.identifier.issn | 0196-9781 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23148 | |
| dc.rights | Default Licence | - |
| dc.subject | Cholecystokinin/blood/*diagnostic use | en |
| dc.subject | Dietary Fats | en |
| dc.subject | Gallbladder/*physiology | en |
| dc.subject | Humans | en |
| dc.subject | Kinetics | en |
| dc.subject | Muscle Contraction | en |
| dc.subject | Muscle, Smooth/physiology | en |
| dc.subject | Oils/diagnostic use | en |
| dc.subject | Peptide Fragments/blood/*diagnostic use | en |
| dc.subject | *Plant Oils | en |
| dc.subject | Sincalide | en |
| dc.subject | Ultrasonics | en |
| dc.title | Cholecystokinin and gallbladder contraction: effect of CCK infusion | en |
| heal.abstract | Cholecystokinin octapeptide (CCK-8) was infused intravenously in five normal subjects. Plasma levels of CCK-8 and infusion concentrations were measured by a specific radioimmunoassay and gallbladder volumes wee monitored using ultrasound. Calculated CCK-8 infusion rates were 16.4, 32.8, and 65.6 pmol.kg(-1) hr(-1). During infusion of the lowest dose plasma concentrations rose from 8 +/- S.E. 5 to 18 +/- 4 pmol.1(-1) equivalent to normal postprandial concentrations of CCK and were accompanied by a 76 +/- 7% reduction in gallbladder volume. Infusion at the two higher rates resulted in 87 +/- 3% and 88 +/- 3% reduction of initial gallbladder volumes returned to 73 +/- 26% of initial volumes within 30 minutes. These studies are consistent with the hypothesis that CCK is the main postprandial stimulus for gall-bladder contraction. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/6283495 | - |
| heal.journalName | Peptides | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1981 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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