Design and synthesis of cationic Aib-containing antimicrobial peptides: conformational and biological studies
Φόρτωση...
Ημερομηνία
Συγγραφείς
Zikou, S.
Koukkou, A. I.
Mastora, P.
Sakarellos-Daitsiotis, M.
Sakarellos, C.
Drainas, C.
Panou-Pomonis, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Wiley-Blackwell
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Peptide Science
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Development of antimicrobial peptides has attracted considerable attention in recent years due to the excessive use of antibiotics, which has led to multiresislant bacteria. Cationic amphiphilic Alb-containing peptide models Ac-(Aib-ArgAib-Leu)(n)-NH2, n = 1-4, and sequential cationic polypeptides (Arg-X-Gly)(n), X = Ala, Val, Leu, were prepared and studied for their antimicrobial and hemolytic activity, as well as for their proteolytic stability. Ac-(Aib-Arg-Aib-Leu)(n)-NH2, n = 2, 3 and the polypeptide (Arg-Leu-Gly)(n) exhibited significant antimicrobial activity, and they were nontoxic at their MIC values and resistant, in particular the Aib-peptide models, to enzymatic degradation. The conformational characteristics of the peptide models were studied by circular dichroism (CD). Structure-activity relationship studies revealed the importance of the amphipathic a-helical conformation of the reported peptides in inducing antimicrobial effects. It is concluded that peptide models comprising cationic amino acids (Arg), helicogenic and noncoding residues (Aib) and/or hydrophobic and helix-promoting components (Leu) may lead to the development of antimicrobial therapeutics. Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.
Περιγραφή
Λέξεις-κλειδιά
cationic aib-containing peptides, antimicrobial activity, proteolytic stability, hemolytic assay, circular dichroism, alpha-aminoisobutyric-acid, tachyplesin-i, membranes, rich, antibiotics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000248164400008
http://onlinelibrary.wiley.com/store/10.1002/psc.876/asset/876_ftp.pdf?v=1&t=hmsy9zgm&s=6f216e46ef55ac6a3a7d55c2906434eb21d088b4
http://onlinelibrary.wiley.com/store/10.1002/psc.876/asset/876_ftp.pdf?v=1&t=hmsy9zgm&s=6f216e46ef55ac6a3a7d55c2906434eb21d088b4
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας