Cryosurgery during topical imiquimod: a successful combination modality for lentigo maligna
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bassukas, I. D.
Gamvroulia, C.
Zioga, A.
Nomikos, K.
Fotika, C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Dermatol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Either cryosurgery or topical imiquimod have been used to treat patients with lentigo maligna in cases where surgery is not feasible. METHODS: We report a patient with lentigo maligna, who was treated with the combination of topical imiquimod and cryosurgery, and review the rationale, which led us to design the present combined cryo-immunological treatment modality. RESULTS: Sustained clearance of lentigo maligna to date (26 months after treatment). The successful treatment of this patient was based on the following rationale: A cryosurgery session during continuing imiquimod application may: (i) reinforce apoptosis of tumor cells; (ii) strengthen antiangiogenesis in the treated tumor; and (iii) build-up a potent tumor-destructive immune response by a cascade of events starting with imiquimod-promoted attraction of immature dendritic antigen-presenting cells (DCs) into the tumor. DCs further mature within the tumor-antigen-rich environment of subsequently cryo-destructed tumor and upon imiquimod-driven migration into the peripheral lymph nodes can stimulate a specific antineoplastic cell-mediated immunity. Finally, continuing imiquimod application after cryosurgery may increase recruitment of activated effector cells into the tumor tissue leading to its destruction. CONCLUSION: Cryosurgery during continued topical imiquimod seems to be a promising treatment for lentigo maligna.
Περιγραφή
Λέξεις-κλειδιά
Adjuvants, Immunologic/*administration & dosage, Administration, Cutaneous, Aged, Aminoquinolines/*administration & dosage, Combined Modality Therapy, *Cryosurgery, Humans, Hutchinson's Melanotic Freckle/*therapy, Male, Skin Neoplasms/*therapy
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18412875
http://onlinelibrary.wiley.com/store/10.1111/j.1365-4632.2008.03562.x/asset/j.1365-4632.2008.03562.x.pdf?v=1&t=h0oyore4&s=444775c337d4c4bcf39589144d89f782bfe7fc3b
http://onlinelibrary.wiley.com/store/10.1111/j.1365-4632.2008.03562.x/asset/j.1365-4632.2008.03562.x.pdf?v=1&t=h0oyore4&s=444775c337d4c4bcf39589144d89f782bfe7fc3b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής